{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:55:14Z","timestamp":1792716914796,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1194,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1111\/j.1365-2133.2012.10893.x","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T19:34:20Z","timestamp":1329766460000},"page":"1262-1269","source":"Crossref","is-referenced-by-count":167,"title":["Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: a randomized clinical trial"],"prefix":"10.1093","volume":"166","author":[{"given":"K.","family":"Togsverd-Bo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.S.","family":"Haak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Thaysen-Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.C.","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.R.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Haedesdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1046\/j.1365-2133.2000.03541.x","article-title":"Prevalence of solar damage and actinic keratosis in a Merseyside population","volume":"142","author":"Memon","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jaad.2006.06.006","article-title":"Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus","volume":"56","author":"Braathen","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1365-2133.2008.08882.x","article-title":"Guidelines for topical photodynamic therapy: update","volume":"159","author":"Morton","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/1011-1344(92)85108-7","article-title":"Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience","volume":"14","author":"Kennedy","year":"1992","journal-title":"J Photochem Photobiol B"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1067\/mjd.2002.119649","article-title":"Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study","volume":"47","author":"Szeimies","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/00015550510032887","article-title":"A randomized multicenter study to compare two treatment regimes of topical methyl aminolevulinate (Metvix\u00ae) PDT in actinic keratosis of the face and scalp","volume":"85","author":"Tarstedt","year":"2005","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB7|cit7","first-page":"1007","volume-title":"Fitzpatrick\u2019s Dermatology in General Medicine","author":"Duncan","year":"2003"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.0022-202X.2005.23843.x","article-title":"Correlation between macroscopic fluorescence and protoporphyrin IX content in psoriasis and actinic keratosis following application of aminolevulinic acid","volume":"125","author":"Smits","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000183753","article-title":"Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy","volume":"218","author":"Gerritsen","year":"2009","journal-title":"Dermatology"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/lsm.20048","article-title":"Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury","volume":"34","author":"Manstein","year":"2004","journal-title":"Lasers Surg Med"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/lsm.20860","article-title":"Fractional CO2 laser-assisted drug delivery","volume":"42","author":"Haedersdal","year":"2010","journal-title":"Lasers Surg Med"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/lsm.21096","article-title":"Enhanced uptake and photoactivation of topical methyl aminolevulinate after fractional CO2 laser pretreatment","volume":"43","author":"Haedersdal","year":"2011","journal-title":"Lasers Surg Med"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1751-1097.1998.tb05177.x","article-title":"Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect","volume":"67","author":"Robinson","year":"1998","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB14|cit14","first-page":"218","article-title":"Preferential relative porphyrin enrichment in solar keratoses upon topical application of delta-aminolevulinic methylester","volume":"68","author":"Fritsch","year":"1998","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/0190-9622(91)70113-G","article-title":"A double blind, vehicle controlled study evaluating masoprocol cream in the treatment of actinic keratoses of the head and neck","volume":"24","author":"Olsen","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1365-2133.2008.08450.x","article-title":"Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded study","volume":"158","author":"Wiegell","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1365-2133.2006.07470.x","article-title":"Intraindividual, right-left comparison of topical methyl aminolaevulinate-photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicentre, randomized controlled study","volume":"155","author":"Morton","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1365-2133.2009.09119.x","article-title":"Photodynamic therapy of actinic keratoses with 8% and 16% methyl aminolaevulinate and home-based daylight exposure: a double-blinded randomized clinical trial","volume":"160","author":"Wiegell","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1067\/mjd.2003.49","article-title":"Photodynamic therapy with topical methyl aminolevulinate (Metvix\u00ae) is effective and safe in the treatment of actinic keratosis: results of a prospective randomized trial","volume":"48","author":"Pariser","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/09546630310012118","article-title":"A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix\u00ae) with single cycle cryotherapy in patients with actinic keratosis: a prospective randomized study","volume":"14","author":"Freeman","year":"2003","journal-title":"J Dermatolog Treat"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB21|cit21","unstructured":"Friedman PM Landau JM Moody MN et\u00a0al. 1550\u2003nm and 1927\u2003nm fractional laser resurfacing for the treatment of actinic keratosis and photodamage: a comparative study American Society for Laser Medicine and Surgery Annual Conference, March 30-April 3, 2011"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB22|cit22","unstructured":"Weiss E Anolik R Brightman L et\u00a0al. Long-term follow-up of 1927\u2003nm fractional resurfacing for actinic keratoses of the face American Society for Laser Medicine and Surgery Annual Conference, March 30-April 3, 2011"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1111\/j.1524-4725.2009.01307.x","article-title":"Enhanced efficacy of photodynamic therapy with methyl 5-aminolevulinic acid in recalcitrant periungual warts after ablative carbon dioxide fractional laser: a pilot study","volume":"35","author":"Yoo","year":"2009","journal-title":"Dermatol Surg"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10103-011-0997-8","article-title":"Lesion dimensions of ablative fractional laser in non-melanoma skin cancer and premalignant lesions","volume":"27","author":"Togsverd-Bo","year":"2012","journal-title":"Lasers Med Sci"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1600-0625.2010.01093.x","article-title":"Penetration enhancement of two topical 5-aminolevulinic acid formulations for photodynamic therapy by erbium:YAG laser ablation of the stratum corneum: continuous versus fractional ablation","volume":"19","author":"Forster","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/lsm.20905","article-title":"Photodynamic photorejuvenation of the face with a combination of microneedling, red light and broadband pulsed light","volume":"42","author":"Clementoni","year":"2010","journal-title":"Lasers Surg Med"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB27|cit27","first-page":"818","article-title":"Enhanced efficacy of photodynamic therapy after fractional resurfacing: fractional photodynamic rejuvenation","volume":"6","author":"Ruiz-Rodriguez","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/j.1365-2133.2011.10265.x","article-title":"Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites","volume":"164","author":"Tyrrell","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2133.2008.08451.x","article-title":"Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate","volume":"158","author":"Wiegell","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1468-3083.2010.03687.x","article-title":"A prospective split-face double-blind randomized placebo-controlled trial to assess the efficacy of methyl aminolevulinate + red light in patients with facial photodamage","volume":"25","author":"Sanclemente","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/j.1365-2133.2012.10893.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1529-8019.2010.01377.x","article-title":"Fractionated CO2 laser skin rejuvenation","volume":"24","author":"Tierney","year":"2011","journal-title":"Dermatol Ther"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2012.10893.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2133.2012.10893.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T13:55:10Z","timestamp":1676382910000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/166\/6\/1262\/6613835"}},"subtitle":["Intensified PDT of AK with fractional CO2 laser"],"short-title":[],"issued":{"date-parts":[[2012,5,25]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2012.10893.x","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5,25]]}}}