{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:26:37Z","timestamp":1762100797609},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T00:00:00Z","timestamp":1205280000000},"content-version":"vor","delay-in-days":5549,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> Monoclonal gammopathy of undetermined significance (MGUS) is different from multiple myeloma (MM) by a low proliferation and by its indolent clinical course. In this study, two biological parameters were investigated which mark the transition from MGUS to MM, i.e. expression of the P\u2010170 glycoprotein associated with the multidrug resistance phenotype (MDR\u20101) and expression of the natural killer cell antigen, CD56. Strong MDR\u20101 expression was found in plasma cells of 32\/38 untreated MGUS as compared with 33\/105 untreated MM stage I\u2013III (84%<jats:italic>v<\/jats:italic> 32%, <jats:italic>P<\/jats:italic>&lt;0.001) and in 0\/10 normal plasma cell samples. CD56 expression in high density was present in 43\/57 analysed untreated MM but in none of 23 MGUS (78%<jats:italic>v<\/jats:italic> 0%<jats:italic>P<\/jats:italic>&lt;0.0001). Plasma cells did characteristically show a low Ki\u201067 proliferation index in 14\/15 MGUS patients (mean 0.05%, range 0\u20130.2%) and a higher index in 25 analysed MM patients (mean 2.31%, range 1\u20137%, <jats:italic>P<\/jats:italic>&lt;0.03).<\/jats:p><jats:p>These data indicate that MDR\u20101 expression together with absence of CD56 expression and a low proliferation index can be used to separate MGUS from MM.<\/jats:p>","DOI":"10.1111\/j.1365-2141.1993.tb04632.x","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T12:37:28Z","timestamp":1205325448000},"page":"63-67","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Analysis of multidrug\u2010resistance (MDR\u20101) glycoprotein and CD56 expression to separate monoclonal gammopathy from multiple myeloma"],"prefix":"10.1111","volume":"83","author":[{"given":"P.","family":"Sonneveld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. G. M.","family":"Durie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"Lokhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Frutiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schoester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. E.","family":"Vela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01534700"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1182\/blood.V73.4.865.865","article-title":"Plasma cell myeloma\u2014new biological insights and advances in therapy","volume":"73","author":"Barlogie B.","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1182\/blood.V75.11.2107.2107","article-title":"Expression of shared idiotypes by paraproteins from patients with multiple myeloma and monoclonal gammopathy of undetermined significance","volume":"75","author":"Berenson J.R.","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.2.377.377"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90141-K"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.3.747.747"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.4049\/jimmunol.138.5.1515","article-title":"Idiotypic analysis of myeloma proteins: anti\u2010DNA activity of monclonal immunoglobulins bearing an SLE idiotypic is more common in IgG than IgM antibodies","volume":"138","author":"Davidson A.","year":"1987","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1182\/blood.V62.2.264.264","article-title":"Thirty\u2010six monoclonal immunoglobulins with antibody activity against cytoskeletal proteins, thyroglobulin and native DNA: immunological studies and clinical correlations","volume":"62","author":"Dighiero G.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1182\/blood.V73.2.566.566","article-title":"Phenotype analysis of myeloma cell lines","volume":"73","author":"Duperray C.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_11_1","first-page":"300","article-title":"Staging and kinetics of multiple myeloma","volume":"13","author":"Durie B.G.M.","year":"1986","journal-title":"Seminars of Oncology"},{"key":"e_1_2_1_12_1","first-page":"25a","article-title":"Cytogenetic and phenotypic analysis of bone marrow plasma cells in patients with drug sensitive and resistant myeloma and MGUS. (Abstract)","volume":"74","author":"Durie B.G.M.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1182\/blood.V73.3.770.770","article-title":"Myelomonocytic myeloma cell line (LB84\u20101)","volume":"73","author":"Durie B.G.M.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.3.913.913"},{"key":"e_1_2_1_15_1","first-page":"815","article-title":"Optimization of immunocytochemical P\u2010glycoprotein assessment in multidrug resistant plasma cell myeloma using 3 antibodies","volume":"63","author":"Grogan T.","year":"1990","journal-title":"Laboratory Investigations"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.13.1133"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.2916"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.4.792"},{"key":"e_1_2_1_19_1","first-page":"123","volume-title":"Clinics in Haematology","author":"Kyle R.A.","year":"1982"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.4049\/jimmunol.139.11.3730","article-title":"Preferential expression of the systemic lupus erythematosus associated idiotype 8\u201312 in sera containing monoclonal immunoglobulins","volume":"139","author":"Livneh A.","year":"1987","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.00471.x-i1"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1182\/blood.V78.3.586.586","article-title":"Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro sensitivity","volume":"78","author":"Marie J.P.","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705283162207"},{"key":"e_1_2_1_24_1","volume-title":"Proc. 3rd Eurage Symposium on Monoclonal Gammapathies","author":"Remels L.","year":"1991"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(85)90082-8"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.V78.1.44.44","article-title":"Multidrug\u2010resistance myeloma: laboratory and clinical effects of Verapamil as a chemo sensitizer","volume":"78","author":"Salmon S.E.","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.9.696"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92353-H"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1182\/blood.V79.6.1496.1496","article-title":"High expression of the mdr multidrug\u2010resistance gene is advanced stage chronic lymphocytic leukemia","volume":"79","author":"Sonneveld P.","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08086.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.1993.tb04632.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.1993.tb04632.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:49:44Z","timestamp":1698299384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.1993.tb04632.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1111\/j.1365-2141.1993.tb04632.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.1993.tb04632.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]},"assertion":[{"value":"2008-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}