{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:11:28Z","timestamp":1761894688976},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T00:00:00Z","timestamp":1205280000000},"content-version":"vor","delay-in-days":4607,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:p><jats:bold>Summary. <\/jats:bold> We report the first case of T\u2010cell 7.5<jats:sup>+<\/jats:sup> hepatosplenic malignant lymphoma in childhood. Tumour\u2010specific oligoprobes were developed against the single Vl\u2010Jl rearrangement of the \u03b4 T\u2010cell receptor (TCR) gene in order to perform minimal residual disease (MRD) studies. Molecular analysis in serial bone marrow samples proved to be of predictive value concerning the clinical outcome. Clonotypic DNA was not detected in peripheral blood during the course of the disease until a refractory terminal leukaemic phase took place 18 months after the diagnosis. This case demonstrates the usefulness of MRU studies to monitor the course of disease in at least some subsets of peripheral T\u2010cell lymphomas.<\/jats:p>","DOI":"10.1111\/j.1365-2141.1995.tb05221.x","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T11:08:31Z","timestamp":1205320111000},"page":"943-946","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Hepatosplenic gamma\u2010delta T\u2010cell malignant lymphoma: report of the first case in childhood, including molecular minimal residual disease follow\u2010up"],"prefix":"10.1111","volume":"90","author":[{"given":"F.","family":"GARCIA\u2010SANCHEZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"MEN\u00c1RGUEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"CRISTOBAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"CANTAI.EJO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"GIL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"ALGARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"VICARIO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1182\/blood.V77.9.2023.2023","article-title":"T\u2010cell receptor 7\u2010A\/CD3+4\u201c8\u201d T\u2010cell acute lymphoblastic leukemias: a distinct subgroup of leukemias in children. A report of five cases","volume":"77","author":"Alfsen G.C.","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood.V75.11.2213.2213","article-title":"Hepatosplenic T\u2010cell lymphoma: sinusal\/sinusoidal localization of malignant cells expressing the T\u2010ccll receptor 70","volume":"75","author":"Farcet J.P.","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_4_1","first-page":"617","article-title":"Expression of the alpha\/beta and gamma\/delta T\u2010cell receptors in 57 cases of peripheral T\u2010cell lymphomas: Identification of a subset of gamma\/delta T\u2010cell lymphomas","volume":"137","author":"Gaulard P.","year":"1990","journal-title":"American Journal of Pathology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90081-Y"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060510"},{"key":"e_1_2_1_7_1","first-page":"1054","article-title":"Rearrangement and diversification of T\u2010cell receptor delta genes in acute lymphoblastic leukemia","volume":"6","author":"Griesinger F.","year":"1992","journal-title":"Leukemia"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01600110"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1182\/blood.V84.2.574.574","article-title":"Characterization of clono specific rearranged T\u2010cell receptor 7\u2010chain genes in lymphomas and leukemias by the polymerase chain reaction and DNA sequencing","volume":"84","author":"Kneb M.","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90179-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1182\/blood.V78.3.739.739","article-title":"Detection of minimal residual disease in T\u2010cell acute lymphoblastic leukemia using polymerase chain reaction predicts impending relapse","volume":"78","author":"Neale G.A.M.","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_12_1","first-page":"269","article-title":"Gamma\/delta T\u2010cell lymphoma with hepatosplcnomegaly: report of a case","volume":"57","author":"Ohno T.","year":"1993","journal-title":"International Journal of Hematology"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90321-6"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.1995.tb05221.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.1995.tb05221.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:45:27Z","timestamp":1698288327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.1995.tb05221.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,8]]}},"alternative-id":["10.1111\/j.1365-2141.1995.tb05221.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.1995.tb05221.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8]]},"assertion":[{"value":"2008-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}