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The patients were followed for a median of 2\u2003years and 22\u2003weeks. Response was evaluated according to M\u2010protein reduction combined with improvement of haemoglobin (Hb) concentration, renal function and pain. Altogether, 14% of patients had a minor response, 14% partial response and 6% complete response. Median survival was 12\u2003months and 29% were alive at last contact. Decline of M\u00a0protein started early and a minimum 25% reduction of M\u00a0protein was detected in 14 of 20 responders (70%) after 3\u2003weeks, and in 20 of 22 responders (91%) after 5\u2003weeks of treatment. Reduction of M\u00a0protein continued for 3\u2003months and further decline was observed in only four patients. The Hb concentration showed a different time course, with a significant increase after 3\u2003months and further increases continued for up to 12\u2003months. Blood concentration levels of thalidomide from 40 patients were used to evaluate the pharmacokinetics of the drug. Rate of absorption, rate of elimination, volume of distribution, clearance and elimination half\u2010life were calculated to be 0\u00b7200\/h, 0\u00b7140\/h, 0\u00b7886\u2003l\/kg, 0\u00b7126\u2003l\/h\/kg and 4\u00b798\u2003h respectively. We found no relationship between thalidomide concentration and effect after 12\u2003weeks.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2004.04879.x","type":"journal-article","created":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T07:40:51Z","timestamp":1103614851000},"page":"149-155","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Early response predicts thalidomide efficiency in patients with advanced multiple 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