{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:35:46Z","timestamp":1790829346057,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T00:00:00Z","timestamp":1100822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Analysis of non\u2010histocompatibility leucocyte antigen (HLA) functional genomics, together with conventional risk factors in haematopoietic stem cell transplantation (HSCT) can lead to predicting outcome in HLA\u2010matched sibling transplant recipients. Polymorphisms of cytokine genes including tumour necrosis factor <jats:italic>\u03b1<\/jats:italic>, interleukin\u201010, interferon <jats:italic>\u03b3<\/jats:italic> and interleukin (IL)\u20106, associate with more severe acute graft\u2010<jats:italic>versus<\/jats:italic>\u2010host disease (aGvHD). Donor genotype for IL\u20101 receptor antagonist (IL\u20101Ra) has been associated with reduced aGvHD severity. Other genotypes (patient IL\u20101Ra, IL\u20106 and donor IL\u20101<jats:italic>\u03b1<\/jats:italic>) have been associated with chronic GvHD, or overall survival (Vitamin D receptor and oestrogen receptor). Polymorphisms within genes associated with host defence\/inflammatory responses (mannose binding lectin genes, myeloperoxidase genes and the FC<jats:italic>\u03b3<\/jats:italic> receptors) have been associated with infections. Polymorphisms of pharmacogenes, such as methylenetetrahydrofolate\u2010reductase, have been associated with aGvHD and other post\u2010transplant complications. The <jats:italic>NOD2<\/jats:italic> gene polymorphism, associated with Crohn's disease, has been shown to be associated with risk of gut GvHD. The majority of the studies have been carried out in single centre HLA\u2010matched sibling cohorts and in relatively few matched unrelated donor transplants. This review gives an overall perspective of the current field of non\u2010HLA genetics with regard to HSCT outcome, clinical relevance and potential application of the results to clinical management of HSCT.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2004.05216.x","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T14:19:51Z","timestamp":1100873991000},"page":"479-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Genetic polymorphisms predicting the outcome of bone marrow transplants"],"prefix":"10.1111","volume":"127","author":[{"given":"Anne M.","family":"Dickinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderson","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Gluckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Holler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Eurobank members","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,19]]},"reference":[{"key":"e_1_2_21_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704200"},{"key":"e_1_2_21_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701478"},{"key":"e_1_2_21_4_1","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.4049\/jimmunol.149.5.1788","article-title":"Tissue distribution of human minor histocompatibility antigens (Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte\u2010defined non\u2010MHC antigens.)","volume":"149","author":"Bueger M.","year":"1992","journal-title":"Journal of Immunology"},{"key":"e_1_2_21_5_1","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1182\/blood.V94.11.3941","article-title":"Recipient tumour necrosis factor\u2010alpha and interleukin\u201010 gene polymorphisms associate with early mortality and acute graft\u2010versus\u2010host disease severity in HLA matched sibling bone marrow transplants","volume":"94","author":"Cavet J.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_21_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.5.1594"},{"key":"e_1_2_21_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.2004.00457.x"},{"key":"e_1_2_21_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02811.x"},{"key":"e_1_2_21_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04510.x"},{"key":"e_1_2_21_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00324-X"},{"key":"e_1_2_21_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200204000-00001"},{"key":"e_1_2_21_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2629"},{"key":"e_1_2_21_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0091"},{"key":"e_1_2_21_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(96)80108-7"},{"key":"e_1_2_21_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/266544a0"},{"key":"e_1_2_21_16_1","first-page":"182s","article-title":"Production, expansion and clonal analysis of T cells with specific HLA\u2010restricted male lysis","volume":"152","author":"Goulmy E.","year":"1980","journal-title":"Journal of Experimental Medicine"},{"key":"e_1_2_21_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/302159a0"},{"key":"e_1_2_21_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.1.93"},{"key":"e_1_2_21_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.2.79"},{"key":"e_1_2_21_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703684"},{"key":"e_1_2_21_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200110270-00019"},{"key":"e_1_2_21_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702126"},{"key":"e_1_2_21_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3543"},{"key":"e_1_2_21_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703409"},{"key":"e_1_2_21_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3568"},{"key":"e_1_2_21_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011838"},{"key":"e_1_2_21_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200210270-00019"},{"key":"e_1_2_21_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704316"},{"key":"e_1_2_21_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(00)02104-7"},{"key":"e_1_2_21_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022060"},{"key":"e_1_2_21_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2001.v7.pm11529488"},{"key":"e_1_2_21_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04314.x"},{"key":"e_1_2_21_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000095899.54052.89"},{"key":"e_1_2_21_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530192100"},{"key":"e_1_2_21_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80330-1"},{"key":"e_1_2_21_36_1","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1182\/blood.V92.10.3943","article-title":"Cytokine gene polymorphisms associating with severe acute graft\u2010versus\u2010host disease in HLA\u2010identical sibling transplants","volume":"92","author":"Middleton P.G.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_21_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703629"},{"key":"e_1_2_21_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704090"},{"key":"e_1_2_21_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0984"},{"key":"e_1_2_21_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)00009-1"},{"key":"e_1_2_21_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3524"},{"key":"e_1_2_21_42_1","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1182\/blood.V93.7.2336","article-title":"Feasibility of immunotherapy of relapsed leukemia with ex vivo\u2010generated cytotoxic T lymphocytes specific for hematopoietic system\u2010restricted minor histocompatibility antigens","volume":"93","author":"Mutis T.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_21_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2603"},{"key":"e_1_2_21_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(03)00009-2"},{"key":"e_1_2_21_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1033"},{"key":"e_1_2_21_46_1","first-page":"24a","article-title":"Association of drug metabolism gene polymorphisms with toxicities, graft\u2010versus\u2010host disease and survival after HLA\u2010identical sibling bone marrow transplantation","volume":"102","author":"Rocha V.","year":"2003","journal-title":"Blood"},{"key":"e_1_2_21_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200108270-00024"},{"key":"e_1_2_21_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364039"},{"key":"e_1_2_21_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000092496.05951.D5"},{"key":"e_1_2_21_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199511270-00010"},{"key":"e_1_2_21_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199709150-00021"},{"key":"e_1_2_21_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"e_1_2_21_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.1.231"},{"key":"e_1_2_21_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.8.3027"},{"key":"e_1_2_21_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7667640"},{"key":"e_1_2_21_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1279"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2004.05216.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2004.05216.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2004.05216.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:36:13Z","timestamp":1697416573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2004.05216.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,19]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1111\/j.1365-2141.2004.05216.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2004.05216.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,19]]},"assertion":[{"value":"2004-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}