{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:13:55Z","timestamp":1783426435669,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>t(11;18)(q21;q21) occurs specifically in mucosa\u2010associated lymphoid tissue (MALT) lymphoma and the translocation generates a functional API2\u2010MALT1 fusion product that activates nuclear factor (NF)<jats:italic>\u03ba<\/jats:italic>B. t(11;18) positive lymphomas usually lack the chromosomal aberrations and microsatellite alterations frequently seen in the translocation\u2010negative MALT lymphomas. To further understand their genetic differences, we investigated gastric MALT lymphomas with and without t(11;18) by comparative genomic hybridisation. In general, both chromosomal gains and losses were far more frequent in t(11;18)\u2010negative (median\u2003=\u20033\u00b74 imbalances) than t(11;18)\u2010positive cases (median\u2003=\u20031\u00b76 imbalances), with gains being more frequent than losses. Recurrent chromosomal gains involving whole or major parts of a chromosome were seen for chromosomes 3, 12, 18 and 22 (23%, 19%, 19% and 27% respectively). Discrete recurrent chromosomal gains were found at 9q34 (11\/26\u2003=\u200342%). Bioinformatic analysis of genes mapping to 9q34 revealed potential targets. Among them, TRAF2 and CARD9 are known interaction partners of BCL10, playing a role in NF<jats:italic>\u03ba<\/jats:italic>B activation. Interphase fluorescent <jats:italic>in situ<\/jats:italic> hybridisation confirmed genomic gain of the TRAF2, CARD9 and MALT1 loci in 5\/6 and 2\/2 cases showing chromosomal gains at 9q34 and 18q21 respectively. The results further highlight the genetic difference between MALT lymphomas with and without t(11;18). Moreover, our findings suggest that genomic gain of genes that modulate NF<jats:italic>\u03ba<\/jats:italic>B activation, such as <jats:italic>MALT1<\/jats:italic>, <jats:italic>TRAF2<\/jats:italic> and <jats:italic>CARD9<\/jats:italic>, may play a role in the pathogenesis of the translocation\u2010negative MALT lymphoma.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.05969.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T16:18:51Z","timestamp":1137773931000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Distinct comparative genomic hybridisation profiles in gastric mucosa\u2010associated lymphoid tissue lymphomas with and without 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