{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:45:05Z","timestamp":1782877505920,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T00:00:00Z","timestamp":1139356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Both the sickle cell trait (HbAS) and <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia are common in many tropical areas. While their individual haematological effects are well described, few studies describe their effects when inherited together. We present data from the Kenyan coast, which suggest that HbAS and <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia may interact to produce specific effects on haematological parameters. Overall, the difference in Hb concentrations between non\u2010thalassaemics (<jats:italic>\u03b1<\/jats:italic><jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b1<\/jats:italic><jats:italic>\u03b1<\/jats:italic>) and <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia homozygotes (\u2212<jats:italic>\u03b1<\/jats:italic>\/\u2212<jats:italic>\u03b1<\/jats:italic>) was greater in non\u2010HbAS (HbAA) (0\u00b763\u2003g\/dl) than in HbAS children (0\u00b725\u2003g\/dl). HbAS also ameliorated both the reduced mean cell volume and mean cell haemoglobin normally associated with the \u2212<jats:italic>\u03b1<\/jats:italic>\/\u2212<jats:italic>\u03b1<\/jats:italic> genotype. Potential mechanisms and implications are discussed.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06006.x","type":"journal-article","created":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T16:14:56Z","timestamp":1139415296000},"page":"206-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Co\u2010inheritance of <i>\u03b1<\/i><sup>+<\/sup>\u2010thalassaemia and sickle trait results in specific effects on haematological parameters"],"prefix":"10.1111","volume":"133","author":[{"given":"Sammy","family":"Wambua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jedidah","family":"Mwacharo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Uyoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Macharia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0713"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830060203"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.72.47"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198202043060504"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000206902"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(05)80150-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2000.00568.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1975.tb00514.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb03977.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1906.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1660"},{"key":"e_1_2_5_13_1","unstructured":"Yates S.N.R.(1995)Human Genetic Diversity and Selection by Malaria.DPhil Thesis.University of Oxford Oxford."}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06006.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06006.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:33:51Z","timestamp":1697430831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06006.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,10]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06006.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06006.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,10]]},"assertion":[{"value":"2006-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}