{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T07:59:40Z","timestamp":1794643180105,"version":"4.9.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T00:00:00Z","timestamp":1142294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The cytokines tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF<jats:italic>\u03b1<\/jats:italic>) and lymphotoxin\u2010<jats:italic>\u03b1<\/jats:italic> (LT<jats:italic>\u03b1<\/jats:italic>) are known to play key roles in B\u2010cell growth, differentiation and maturation. Genetic polymorphism within regulatory regions of these cytokine genes can alter expression levels and may be important in development of lymphoid malignancy. This study investigates a number of single nucleotide polymorphisms (SNPs) and microsatellite variants present within these genes in a large cohort of non\u2010Hodgkin lymphoma (NHL) cases including 211 cases of follicular lymphoma (FL) and 281 cases of diffuse large B\u2010cell lymphoma (DLBCL), and 478 unaffected controls. The study investigated whether particular alleles at these loci, or their combination across the TNF region in the form of haplotypes, may act as markers for predisposition and development of NHL. The study provided evidence for an influence of the TNF region in the susceptibility to NHL, whereby the loci \u2212863, \u2212857, <jats:italic>TNFe<\/jats:italic> and <jats:italic>TNFd<\/jats:italic> categorised five haplotype groups over which risk of both FL and DLBCL varied significantly. Prediction of disease risk was improved by the addition of loci to the haplotype, demonstrating the importance of considering the haplotype\u2010specific context of the loci in genetic risk assessment.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06030.x","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T09:06:33Z","timestamp":1142327193000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association between non\u2010Hodgkin lymphoma and haplotypes in the TNF region"],"prefix":"10.1111","volume":"133","author":[{"given":"Charlotte F.","family":"Spink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh J.","family":"Keen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona K.","family":"Mensah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham R.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff L.","family":"Bidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth J.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.2.182"},{"key":"e_1_2_6_3_1","first-page":"364","article-title":"Tumour necrosis factor\u2010alpha in malignant disease","volume":"15","author":"Abrahamsson J.","year":"1993","journal-title":"American Journal of Pediatric Hematology\/Oncology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_6_5_1","first-page":"103","article-title":"Tumour necrosis factor in solid tumors: increased blood levels in the metastic disease","volume":"6","author":"Ardizzoia A.","year":"1992","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02935501"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8535"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91782-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.142657.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/8.1.23"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240825"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/117.2.331"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb03002.x"},{"key":"e_1_2_6_14_1","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe E.S.","year":"2001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/BF03401767","article-title":"Functional analysis of a human tumor necrosis factor alpha (TNF alpha) promoter polymorphism related to joint damage in rheumatoid arthritis","volume":"4","author":"Kaijzel E.L.","year":"1998","journal-title":"Molecular Medicine"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271020"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2367"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/genetics\/49.1.49","article-title":"The interaction of selection and linkage: I. 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