{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:08:24Z","timestamp":1789765704426,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T00:00:00Z","timestamp":1145318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The incidence of infections among patients with thalassaemia and the role of risk factors for infection are uncertain. We studied the occurrence of infections necessitating hospitalisation in 92 homozygous <jats:italic>\u03b2<\/jats:italic>\u2010thalassaemia patients who had been followed longitudinally for decades, and investigated the role of potential risk factors for these infections. Pneumonia accounted for 26% of the infections and fever of unknown origin for 14%. <jats:italic>Staphylococcus aureus<\/jats:italic> was the major pathogen possibly related to injections associated with intensive chelation with deferoxamine. There was a significant increase in the rate of infection over time, notably after 15\u2003years. Splenectomy correlated with the incidence of infection (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001) without being confounded by other variables and with highest frequencies of infections present after 10\u2003years. A direct correlation between iron overload and infection was evident only before the initiation of iron\u2010chelating treatment (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b701). Following initiation of deferoxamine, paradoxically, the infection rate increased (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7046). The combination of splenectomy and deferoxamine treatment was associated with the highest adjusted infection rate. Parathyroid dysfunction and glucose\u20106\u2010phosphate dehydrogenase deficiency were significantly associated with infection (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b702 and <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b704 respectively). The infection rate in thalassaemia is affected mainly by the duration of the disease and is increased by splenectomy and, in the long term, by treatment with deferoxamine.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06082.x","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T03:36:08Z","timestamp":1145504168000},"page":"667-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Severe infections in thalassaemic patients: prevalence and predisposing factors"],"prefix":"10.1111","volume":"133","author":[{"given":"Galia","family":"Rahav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Volach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Rund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer A.","family":"Rachmilewitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Goldfarb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80131-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/515025"},{"key":"e_1_2_5_4_1","first-page":"521","article-title":"Severe infection in thalassemia: a prospective study","volume":"23","author":"Aswapokee P.","year":"1987","journal-title":"Birth defects Original Article Series"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2001.0904"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830350104"},{"key":"e_1_2_5_7_1","first-page":"607","article-title":"Infectious complications after splenectomy","volume":"150","author":"Carlstedt A.","year":"1984","journal-title":"Acta Chirurgica Scandinavica"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01732885"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/367656"},{"key":"e_1_2_5_10_1","first-page":"169","article-title":"Glucose\u20106\u2010phosphate dehydrogenase deficiency and infection: a study of hospitalized patients in Iran","volume":"52","author":"Clark M.","year":"1979","journal-title":"The Yale Journal of Biology and Medicine"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1137.x"},{"key":"e_1_2_5_12_1","first-page":"486","volume-title":"Hematology: Basic Principles and Practice","author":"Forget B.G.","year":"2000"},{"key":"e_1_2_5_13_1","first-page":"495","article-title":"Deaths in beta\u2010thalassemia\/Hb E patients secondary to infections","volume":"23","author":"Fucharoen S.","year":"1987","journal-title":"Birth Defects Original Article Series"},{"key":"e_1_2_5_14_1","first-page":"1","volume-title":"Hospital Epidemiology and Infection Control","author":"Gaynes R.P.","year":"1996"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1999.v34.aajkd0344b0030"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780904"},{"key":"e_1_2_5_17_1","first-page":"505","article-title":"Infection in thalassemia: a retrospective study of 1018 patients with \u03b2\u2010thalassemia\/HbE disease","volume":"23","author":"Issaragrisil S.","year":"1987","journal-title":"Birth Defects Original Article Series"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010151114949"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80202-0"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82206-1"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199205000-00009"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30991048786.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198112000-00020"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310903"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218277"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/713842280"},{"key":"e_1_2_5_27_1","first-page":"318","article-title":"Bacterial infection in patients with transfusion\u2010dependent beta\u2010thalassemia in central Taiwan","volume":"41","author":"Peng C.T.","year":"2000","journal-title":"Acta Paediatrica Taiwanica"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.1402955.x"},{"key":"e_1_2_5_29_1","first-page":"487","article-title":"Infections and Cooley disease","volume":"23","author":"Schiliro G.","year":"1987","journal-title":"Birth Defects Original Article Series"},{"key":"e_1_2_5_30_1","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1001\/jama.1982.03330180039029","article-title":"Postsplenectomy sepsis and mortality in adults","volume":"248","author":"Schwartz P.E.","year":"1982","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2003.00300.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200104000-00005"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200011000-00027"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983565"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1086\/378062"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.0320s1070.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/1024533031000081414"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06082.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06082.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T18:05:05Z","timestamp":1697393105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06082.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,16]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06082.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06082.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,16]]},"assertion":[{"value":"2006-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}