{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:50:15Z","timestamp":1791571815323,"version":"4.3.4"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T00:00:00Z","timestamp":1145318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The expression of the <jats:italic>VAV<\/jats:italic> proto\u2010oncogene in 57 patients with chronic myeloproliferative disease (CMD), B\u2010cell acute lymphoblastic leukaemia (B\u2010ALL) and B\u2010cell non\u2010Hodgkin Lymphoma (B\u2010NHL), and 61 with B\u2010cell chronic lymphocytic leukaemia (B\u2010CLL) was analysed. VAV overexpression was observed in 19\u00b75% of cases and 81% of VAV\u2010positive tumours also displayed VAV phosphorylation. Overexpression was not observed in B\u2010ALL or CMD, but 13% of B\u2010NHL and 34\u00b74% of B\u2010CLL patients (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7002) overexpressed VAV. The overexpression and phosphorylation of VAV was detected more frequently in 13q\u2010 chronic lymphocytic leukaemias (71.4%) <jats:italic>versus<\/jats:italic> other B\u2010CLLs (23\u00b74%, <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7001). Overexpression of VAV protein is a frequent event in patients with B\u2010CLL displaying loss of 13q sequences.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06094.x","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T03:36:08Z","timestamp":1145504168000},"page":"642-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Overexpression of the <i>VAV<\/i> proto\u2010oncogene product is associated with B\u2010cell chronic lymphocytic leukaemia displaying loss on 13q"],"prefix":"10.1111","volume":"133","author":[{"given":"Rosario M.","family":"Prieto\u2010S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan L.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma C.","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas San","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xos\u00e9 R.","family":"Bustelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas M.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.5.1461-1477.2000"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg316"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01148"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.11.024"},{"key":"e_1_2_7_6_1","first-page":"481","article-title":"Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukaemia M4Eo","volume":"85","author":"Hern\u00e1ndez J.M.","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.5.1678-1691.2000"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600617"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.8.4337"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06094.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06094.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T18:06:04Z","timestamp":1697393164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06094.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,16]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06094.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06094.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,16]]},"assertion":[{"value":"2006-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}