{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:57:14Z","timestamp":1715943434966},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,4,24]],"date-time":"2006-04-24T00:00:00Z","timestamp":1145836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fanconi anaemia (FA) and Nijmegen breakage syndrome (NBS) carry a high risk of haematological cancer. Affected cellular pathways may be modulated in sporadic malignancies and silencing of <jats:italic>FANCF<\/jats:italic> through methylation has been shown to cause somatic disruption of the FA pathway. Combined bisulphite restriction analysis for methylation of <jats:italic>FANCF<\/jats:italic>, <jats:italic>FANCB<\/jats:italic> and <jats:italic>NBS1<\/jats:italic> was used to investigate 81 sporadic acute childhood leukaemias. No methylation was detected at any associated CpG sites analysed. This does not exclude very low levels of <jats:italic>FANCF<\/jats:italic>, <jats:italic>FANCB<\/jats:italic> or <jats:italic>NBS1<\/jats:italic> methylation, but suggests other factors are responsible for chemo\u2010sensitivity and chromosomal instability in sporadic childhood leukaemia.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06107.x","type":"journal-article","created":{"date-parts":[[2006,4,24]],"date-time":"2006-04-24T08:40:05Z","timestamp":1145868005000},"page":"61-63","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["No evidence of significant silencing of Fanconi genes <i>FANCF<\/i> and <i>FANCB<\/i> or Nijmegen breakage syndrome gene <i>NBS1<\/i> by DNA hyper\u2010methylation in sporadic childhood leukaemia"],"prefix":"10.1111","volume":"134","author":[{"given":"Stefan","family":"Meyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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