{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:18:39Z","timestamp":1789730319444,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T00:00:00Z","timestamp":1151539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Elevated velocity in the internal carotid artery (ICA) or middle cerebral artery (MCA), detected by transcranial Doppler (TCD) ultrasonography, predicts an increased risk of stroke in children with sickle cell disease (SCD). Although strokes also occur in an anterior cerebral artery (ACA) distribution, the significance of elevated velocity in this vessel has not been determined previously. We assessed the effect of elevated ACA velocity on stroke risk using the results of the first adequate TCD study performed on 1975 children as part of The Stroke Prevention Trial in Sickle Cell Anemia (STOP). Elevated ACA velocity (\u2265170\u2003cm\/s) was associated with an increased risk of stroke (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b70013) after adjusting for the ICA\/MCA classification. Among subjects with normal ICA\/MCA velocity, the risk of stroke was more than 10\u2010fold greater in those with elevated compared with normal ACA velocity (2\u00b713 and 0\u00b720 per 100\u2003patient\u2010years, respectively, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001); risk more than doubled with elevated compared with normal ACA velocity in those already at high risk due to abnormal ICA\/MCA findings (7\u00b756 vs. 3\u00b722 per 100\u2003patient\u2010years, <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7042). Few of the strokes in those with elevated ACA velocity occurred in an ACA distribution, suggesting changes in blood flow velocity in anterior vessels may be associated with diffuse arterial disease or, alternatively, manifest collateral flow from compromised middle cerebral vessels.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06193.x","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:32:12Z","timestamp":1151627532000},"page":"333-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Elevated blood flow velocity in the anterior cerebral artery and stroke risk in sickle cell disease: extended analysis from the STOP trial"],"prefix":"10.1111","volume":"134","author":[{"given":"Janet L.","family":"Kwiatkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Clark","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the STOP Trial Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1972"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.8.1073"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202273260905"},{"key":"e_1_2_6_5_1","first-page":"41","volume-title":"Transcranial Doppler","author":"Adams R.J.","year":"1992"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420505"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(97)00099-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V101.6.2401"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0636"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.134.6.1209"},{"key":"e_1_2_6_12_1","volume-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch J.","year":"1980"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00607263"},{"key":"e_1_2_6_14_1","first-page":"71","article-title":"Vascular lesions in the central nervous system in sickle cell disease (neuropathology)","volume":"1","author":"Koshy M.","year":"1990","journal-title":"Journal of the Association for Academic Minority Physicians"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200405000-00014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.117580"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.119593"},{"key":"e_1_2_6_18_1","first-page":"965","article-title":"The spectrum of brain MR abnormalities in sickle\u2010cell disease: a report from the Cooperative Study of Sickle Cell Disease","volume":"17","author":"Moser F.G.","year":"1996","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2001.tb00063.x"},{"key":"e_1_2_6_20_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene\u2010Frempong K.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200606"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V63.1.162.162"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050314"},{"issue":"1","key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1007\/BF03545573","article-title":"Detection of cerebrovascular disease in patients with sickle cell disease using transcranial Doppler sonography:correlation with MRI, MRA and conventional angiography","volume":"25","author":"Verlhac S.","year":"1995","journal-title":"Pediatric Radiology"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00451759"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06193.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06193.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:07:53Z","timestamp":1697443673000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06193.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,29]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06193.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06193.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,29]]},"assertion":[{"value":"2006-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}