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In severe cases, venous ulcers may develop. The frequency of PTS is likely to be reduced by preventing DVT with the use of effective thromboprophylaxis in high\u2010risk patients and settings and by minimising the risk of ipsilateral DVT recurrence. Use of compression stockings for 2\u2003years after DVT appears to reduce the incidence and severity of PTS but issues remain regarding their use and effectiveness. Future research should focus on elucidating the pathophysiology and risk factors for PTS, assessing the safety and effectiveness of catheter\u2010directed thrombolysis to prevent PTS and evaluating the optimal use of compression stockings to prevent and treat PTS. In addition, new therapies to treat PTS should be sought and evaluated.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06200.x","type":"journal-article","created":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T17:48:36Z","timestamp":1152121716000},"page":"357-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["The post\u2010thrombotic syndrome: progress and pitfalls"],"prefix":"10.1111","volume":"134","author":[{"given":"Susan R.","family":"Kahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200106000-00004"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/s-0037-1613447","article-title":"Body mass index is associated with the development of the post\u2010thrombotic 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