{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:46:12Z","timestamp":1762865172228},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Thrombosis occurs in 37% of children with acute lymphoblastic leukaemia (ALL) and is related to an <jats:sc>l<\/jats:sc>\u2010asparaginase\u2010induced acquired antithrombin (AT) deficiency. The incidence dictates the need for anticoagulant prophylaxis. Direct thrombin inhibitors (DTI) are independent of AT for effect and may thus have advantages in this population. The objective of this study was to determine the interaction of an AT deficiency with the anticoagulant effects of a DTI and a low molecular weight heparin (LMWH). Plasma samples from children with ALL were pooled (mean AT 0\u00b753\u2003U\/ml). LMWH 0\u00b73 and 0\u00b77\u2003U\/ml or melagatran 0\u00b73 and 0\u00b75\u2003<jats:italic>\u03bc<\/jats:italic>mol\/l were added to the pools, then divided and AT was added back to one aliquot. In additional experiments, AT was added to AT immuno\u2010depleted plasma. Endogenous thrombin generation capacity (ETGC) was assessed by the continuous method. In plasma with LMWH, there was a 66\u201388% decrease in ETGC in AT\u2010normalised samples compared with neat. Conversely, no significant difference in ETGC with or without AT added for melagatran was seen. Experiments with AT\u2010depleted plasma showed no effect of AT level on anticoagulant activity of DTI, but a significant relationship for LMWH. By contrast to LMWH, DTI provides a consistent anticoagulant response independent of AT levels in children with AT deficiency.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06209.x","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T13:57:42Z","timestamp":1153403862000},"page":"526-531","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Comparison of the anticoagulant effect of a direct thrombin inhibitor and a low molecular weight heparin in an acquired antithrombin deficiency in children with acute lymphoblastic leukaemia treated with <scp>l<\/scp>\u2010asparaginase: an <i>in vitro<\/i> study"],"prefix":"10.1111","volume":"134","author":[{"given":"Stefan","family":"Kuhle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Bajzar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patsy","family":"Vegh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Halton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Cherrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"McCusker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Abshire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1055\/s-0038-1642714","article-title":"Developmental hemostasis: relevance to thromboembolic complications in pediatric patients","volume":"74","author":"Andrew M.","year":"1995","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.1.165.165"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199401000-00005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000156515.49293.F8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994942"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10720"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01417.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00034.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00890.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.01100.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035162"},{"key":"e_1_2_7_13_1","first-page":"V88","article-title":"The THROMBOTECT trial \u2013 the first randomised multicenter interventional study on prevention of thromboembolism in induction chemotherapy for childhood acute lymphoblastic leukemia","volume":"24","author":"Greiner J.","year":"2004","journal-title":"H\u00e4mostaseologie"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(00)00399-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830470302"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1055\/s-0038-1649638","article-title":"Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential","volume":"70","author":"Hemker H.C.","year":"1993","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4195"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70144-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.07.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04309-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200402000-00038"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1051\/ject\/2004362178","article-title":"Argatroban usage for anticoagulation for ECMO on a post\u2010cardiac patient with heparin\u2010induced thrombocytopenia","volume":"36","author":"Mejak B.","year":"2004","journal-title":"The Journal of Extra-Corporeal Technology"},{"key":"e_1_2_7_23_1","first-page":"120","article-title":"Effect of disease and chemotherapy on hemostasis in children with acute lymphoid leukemia","volume":"16","author":"Mitchell L.G.","year":"1994","journal-title":"The American Journal of Pediatric Hematology\/Oncology"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1182\/blood.V83.2.386.386","article-title":"Increased endogenous thrombin generation in children with acute lymphoblastic leukemia: risk of thrombotic complications in l\u2010asparaginase\u2010induced antithrombin III deficiency","volume":"83","author":"Mitchell L.","year":"1994","journal-title":"Blood"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11042"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1160\/TH02-11-0283","article-title":"Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l\u2010asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study","volume":"90","author":"Mitchell L.","year":"2003","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3_suppl.645S"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14841-6"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1055\/s-0038-1646334","article-title":"Treatment of venous thromboembolism in patients with congenital deficiency of antithrombin III","volume":"68","author":"Schulman S.","year":"1992","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030104"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35285"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005274550"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.9.3007"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134685.75813.EB"},{"key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1160\/TH05-03-0197","article-title":"Effects of antithrombin and heparin cofactor II levels on anticoagulation with intimatan","volume":"94","author":"Tanaka K.A.","year":"2005","journal-title":"Thrombosis and Haemostasis"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06209.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06209.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:36:37Z","timestamp":1697416597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06209.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,31]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06209.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06209.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,31]]},"assertion":[{"value":"2006-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}