{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:10:05Z","timestamp":1791544205077,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The possible relationships between biochemical measurements and both densitometric and radiographic indexes of skeletal fragility were evaluated in 65 postmenopausal women with monoclonal gammopathy of undetermined significance (MGUS). There was a significantly higher prevalence of vertebral fractures in the MGUS group compared with a control population (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030\u00b7001). The MGUS patients were then grouped according to the presence or absence of at least one mild vertebral fracture. Patients with fractures (Fx, <jats:italic>n<\/jats:italic>\u2003=\u200334) were older (62\u00b78\u2003\u00b1\u20036\u00b71\u2003years), with long\u2010standing disease (8\u00b78\u2003\u00b1\u20037\u00b71\u2003years) when compared with those without fractures (NFx, <jats:italic>n<\/jats:italic>\u2003=\u200331; 59\u00b77\u2003\u00b1\u20035\u00b70\u2003years, <jats:italic>P<\/jats:italic>\u2003\u2264\u20030\u00b705 and 5\u00b78\u2003\u00b1\u20034\u00b71\u2003years, <jats:italic>P<\/jats:italic>\u2003\u2264\u20030\u00b705). The receptor activator of nuclear factor kappa\u2010B ligand\/osteoprotegerin ratio was higher in Fx compared with NFx (0\u00b7092\u2003\u00b1\u20030\u00b7018 vs. 0\u00b7082\u2003\u00b1\u20030\u00b7020; <jats:italic>P<\/jats:italic>\u2003\u2264\u20030\u00b705). Lumbar spine (0\u00b7811\u2003\u00b1\u20030\u00b714 vs. 0\u00b7956\u2003\u00b1\u20030\u00b712\u2003g\/cm<jats:sup>2<\/jats:sup>), femoral neck (0\u00b7660\u2003\u00b1\u20030\u00b709 vs. 0\u00b7747\u2003\u00b1\u20030\u00b710\u2003g\/cm<jats:sup>2<\/jats:sup>) and total bone mineral density (BMD) (0\u00b7788\u2003\u00b1\u20030\u00b711 vs. 0\u00b7884\u2003\u00b1\u20030\u00b711\u2003g\/cm<jats:sup>2<\/jats:sup>) were lower (all <jats:italic>P<\/jats:italic>\u2003\u2264\u20030\u00b7001) in Fx\u2010MGUS compared with Nfx patients. Receiver operating characteristic curves identified lumbar BMD as the variable that best predicted vertebral fractures (area under the curve 0\u00b7817; 95% confidence interval, 0\u00b7713\u20130\u00b7921). This study provides an indication for the measurement of BMD in MGUS patients, as a means of predicting vertebral fractures, especially in those that are asymptomatic. Patients with prevalent fractures should undergo pharmacological treatment to prevent further fractures.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06217.x","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T09:20:12Z","timestamp":1153214412000},"page":"485-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Lumbar bone mineral density as the major factor determining increased prevalence of vertebral fractures in monoclonal gammopathy of undetermined significance"],"prefix":"10.1111","volume":"134","author":[{"given":"Jessica","family":"Pepe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Petrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Nofroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Fassino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Diacinti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Minisola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809059252"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2001.00055.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.12.2267"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080915"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110716"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.13.3527"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1093\/clinchem\/41.11.1560","article-title":"Monoclonal antibody assay for measuring bone specific alkaline phosphatase activity in serum","volume":"41","author":"Gomez B.","year":"1995","journal-title":"Clinical Chemistry"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200564"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/clinchem\/39.3.529","article-title":"Determination of vitamin D status by radioimmunoassay with 125I labeled tracer","volume":"39","author":"Hollis B.W.","year":"1993","journal-title":"Clinical Chemistry"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.00505.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1093\/clinchem\/43.11.2076","article-title":"Improved purification of human bone sialoprotein and development of a homologous radioimmunoassay","volume":"43","author":"Karmatschek M.","year":"1997","journal-title":"Clinical Chemistry"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.1.21"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.0301212"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-6009(08)80095-5"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005815"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.9.3743"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1757-4"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05092.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050317"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1633-2"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/clinchem\/44.11.2281","article-title":"Serum CrossLaps one step ELISA.\u00a0First application of monoclonal antibodies for measurement of bone\u2010related degradation products from C\u2010terminal telopeptides of type I collagen","volume":"44","author":"Rosenquist C.","year":"1998","journal-title":"Clinical Chemistry"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0380"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.4065\/75.9.888"},{"key":"e_1_2_5_26_1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/clinchem\/47.4.686","article-title":"Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis","volume":"47","author":"Woitge H.W.","year":"2001","journal-title":"Clinical Chemistry"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06217.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06217.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:36:33Z","timestamp":1697416593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06217.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,31]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06217.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06217.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,31]]},"assertion":[{"value":"2006-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}