{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:12:48Z","timestamp":1789809168209,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The incidence, characteristics and risk factors for the development of osteonecrosis of the jaw (ONJ) were evaluated among 303 myeloma patients. Only patients who received bisphosphonates developed ONJ (28\/254; 11%). Zoledronic acid produced 9\u00b75\u2010fold greater risk for developing ONJ than pamidronate alone (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7042) and 4\u00b75\u2010fold greater risk than subsequent use of pamidronate\u2003+\u2003zoledronic acid (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7018). Use of thalidomide and number of bisphosphonate infusions also increased the risk for ONJ by 2\u00b74\u2010fold (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7043), and 4\u00b79\u2010fold respectively (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7012). ONJ developed earlier among patients receiving zoledronic acid. Our data indicates that administration of zoledronic acid for more than 2\u2003years or in combination with thalidomide requires caution in myeloma.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06230.x","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T16:19:27Z","timestamp":1154535567000},"page":"620-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":214,"title":["Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: a single\u2010centre experience in 303 patients"],"prefix":"10.1111","volume":"134","author":[{"given":"Kostas","family":"Zervas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Verrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisis","family":"Teleioudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Vahtsevanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Banti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Mihou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Krikelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.2465"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8670"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.2.593"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.037"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200507073530120"},{"key":"e_1_2_5_7_1","first-page":"190","article-title":"Osteonecrosis of the jaws in myeloma: analysis of risk factors including time dependency of Aredia and Zometa use, steroid use and underlying dental problems","volume":"90","author":"Durie B.G.M.","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(89)90075-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jop.2006.2.1.7"},{"key":"e_1_2_5_10_1","first-page":"2893","article-title":"Zoledronic acid induces significant and long\u2010lasting modifications of circulating angiogenic factors in cancer patients","volume":"9","author":"Santini D.","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/08869634.2002.11746222","article-title":"Medullary and odontogenic disease in the painful jaw: clinicopathological review of 500 cases","volume":"20","author":"Shankland W.E.","year":"2003","journal-title":"Cranio"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05867.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2004.40.1.799436"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06230.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06230.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:30:00Z","timestamp":1697409000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06230.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,18]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06230.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06230.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,18]]},"assertion":[{"value":"2006-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}