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Heat shock protein 90 (HSP90) is a molecular chaperon to proteins that regulate cell cycle and survival. 17\u2010allylamino\u201017\u2010demethoxy\u2010geldanamycin (17\u2010AAG), a HSP90 small molecule inhibitor, induced G<jats:sub>0\/1<\/jats:sub> cell cycle arrest and cell death in a dose\u2010 and time\u2010dependent manner in MCL cell lines. This effect was associated with the downregulation of cyclin D1, cdk4 and Akt, depletion of Bid, and activation of the intrinsic\/mitochondrial caspase pathway. 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