{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:35:29Z","timestamp":1791214529839,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T00:00:00Z","timestamp":1156809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The effect of maternal <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia on pregnancy was assessed in the north coastal region of Papua New Guinea (PNG), where malaria is hyperendemic and <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia is extremely common. In a prospective study of 987 singleton hospital deliveries, we correlated maternal <jats:italic>\u03b1<\/jats:italic>\u2010globin genotype with markers of reproductive fitness (age in primigravidae, gravidity, pregnancy interval and the number of miscarriages and stillbirths), <jats:italic>Plasmodium falciparum<\/jats:italic><jats:italic>(P. falciparum)<\/jats:italic> infection of the mother and placenta, maternal haemoglobin, preterm delivery and birthweight. The frequency of the \u2212<jats:italic>\u03b1<\/jats:italic> genotype in mothers was 0\u00b761. Markers of reproductive fitness were similar in women with and without <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia. Median haemoglobin concentration during pregnancy and after delivery was about 1\u00b70\u2003g\/dl lower in homozygous <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia than in women with a normal <jats:italic>\u03b1<\/jats:italic>\u2010 globin genotype (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030\u00b7001). The frequency of placental <jats:italic>P. falciparum<\/jats:italic> infection and systemic malaria infection after delivery showed no consistent relationship to <jats:italic>\u03b1<\/jats:italic>\u2010globin genotype. The frequency of preterm delivery and low birthweight did not vary significantly according to maternal <jats:italic>\u03b1<\/jats:italic>\u2010globin genotype. Maternal <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia does not affect reproductive fitness or susceptibility to malaria during pregnancy. Although median haemoglobin concentration was significantly lower in mothers homozygous for <jats:italic>\u03b1<\/jats:italic><jats:sup>+<\/jats:sup>\u2010thalassaemia than those with a normal <jats:italic>\u03b1<\/jats:italic>\u2010globin genotype, this did not result in an adverse outcome of pregnancy.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06274.x","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T07:40:52Z","timestamp":1156837252000},"page":"235-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>\u03b1<\/i><sup>+<\/sup>\u2010Thalassaemia and pregnancy in a malaria endemic region of Papua New 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