{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:52:31Z","timestamp":1722930751151},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T00:00:00Z","timestamp":1157932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Trisomy 21 is common in <jats:italic>ETV6\/RUNX1<\/jats:italic>\u2010positive acute lymphoblastic leukaemia (ALL); both these aberrations are associated with a favourable outcome. The prognostic impact of +21 as a sole cytogenetic change could be due to a cryptic t(12;21)(p13;q22). The occurrence of <jats:italic>ETV6\/RUNX1<\/jats:italic> was determined in 66 childhood ALLs with an acquired +21 and a chromosome number &lt;51. <jats:italic>ETV6\/RUNX1<\/jats:italic> was found in 45% of cases and in the majority (10\/18; 56%) of ALLs with sole +21. Event\u2010free survival did not differ between the t(12;21)\u2010positive and \u2010negative cases. Thus, the prognostic impact of +21 is not attributable to cryptic <jats:italic>ETV6\/RUNX1<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06286.x","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T07:01:58Z","timestamp":1157958118000},"page":"352-354","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High incidence of the <i>ETV6\/RUNX1<\/i> fusion gene in paediatric precursor B\u2010cell acute lymphoblastic leukaemias with trisomy 21 as the sole cytogenetic change: a Nordic series of cases diagnosed 1989\u20132005"],"prefix":"10.1111","volume":"135","author":[{"given":"Kristina","family":"Karrman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Forestier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette K.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"Autio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Borgstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre","family":"Heim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Heinonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randi","family":"Hovland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitte","family":"Kerndrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Nordic Society of Paediatric Haematology and Oncology (NOPHO) and the NOPHO Leukaemia Cytogenetic Study Group (NLCSG)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,28]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403471"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.2.571"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2000.90103.x"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00272-7"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199903)24:3<272::AID-GCC13>3.0.CO;2-U"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.11.4252.4252"},{"key":"e_1_2_3_8_1","unstructured":"Mitelman F. 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