{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:41:08Z","timestamp":1791009668757,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T00:00:00Z","timestamp":1157673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acquired pure red cell aplasia (PRCA) is a rare disorder of erythropoiesis that can develop in association with a thymoma. Optimal management of this subgroup is unclear, and there have been few series reporting long\u2010term clinical outcomes. Here, we report features of 13 patients treated for PRCA associated with thymoma over 50\u2003years at our institution. Surgical resection of the thymoma was insufficient for normalisation of erythropoiesis in all cases. T\u2010cell gene rearrangement studies did not routinely demonstrate a clonal process, and ciclosporin and anti\u2010thymocyte globulin were effective adjuvant treatments. However, treatment\u2010related morbidity was high, with frequent infectious complications.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06295.x","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T19:45:48Z","timestamp":1157744748000},"page":"405-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Pure red cell aplasia associated with thymoma: clinical insights from a 50\u2010year single\u2010institution experience*"],"prefix":"10.1111","volume":"135","author":[{"given":"Carrie A.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Steensma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,28]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.11.4831.bloodjournal87114831"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood.V63.2.277.277","article-title":"Studies on pure red cell aplasia. 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Results of immunosuppressive treatment of 37 patients","volume":"63","author":"Clark D.","year":"1984","journal-title":"Blood"},{"key":"e_1_2_4_4_1","first-page":"275","article-title":"The biology of pure red cell aplasia","volume":"28","author":"Dessypris E.","year":"1991","journal-title":"Seminars in Hematology"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02429.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097761"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690100900106"},{"key":"e_1_2_4_8_1","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1182\/blood.V87.7.3000.bloodjournal8773000","article-title":"Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities","volume":"87","author":"Lacy M.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_4_9_1","first-page":"285","article-title":"Therapy of pure red cell aplasia","volume":"28","author":"Marmont A.","year":"1991","journal-title":"Seminars in Hematology"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/021849230201000213"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)63116-5"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06295.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06295.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:23:11Z","timestamp":1697455391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06295.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,28]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06295.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06295.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,28]]},"assertion":[{"value":"2006-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}