{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:50:28Z","timestamp":1787698228313,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mucositis is a known complication of autologous stem cell transplantation (ASCT). This study retrospectively reviewed 191 patients with lymphoid malignancies undergoing ASCT following a uniform mobilising regimen of etoposide (VP\u201016)\/granulocyte colony\u2010stimulating factor and a uniform high\u2010dose preparative regimen of busulfan\/cyclophosphamide\/VP\u201016. Eighty\u2010seven patients experienced severe mucositis (modified Oral Mucositis Assessment Scale \u22651). Patient characteristics compared between mucositis groups were balanced according to disease status, prior exposure to radiation therapy, time from radiation therapy and actual body weight. Log\u2010rank analysis revealed that severe mucositis was associated with inferior overall survival (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7002). A 12\u2010month landmark analysis showed this difference in survival occurred within 1\u2003year post\u2010transplant. Multivariate analysis of all\u2010cause mortality showed lower pretransplant albumin and severe mucositis to be significant risk factors. Multivariate analysis for relapse mortality revealed severe mucositis to be a risk factor (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7047), while lower pretransplant albumin was significant for non\u2010relapse mortality (NRM; <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7009). Kaplan\u2013Meier estimates of survival based on relapse and NRM were significantly worse for patients with severe mucositis. Reduced pretransplant forced expiratory volume in 1\u2003s (<jats:italic>FEV<\/jats:italic><jats:sub>1<\/jats:sub>) and carbon monoxide (CO) diffusing capacity (DLCO) were also associated with severe mucositis. Our data suggest that studies of new treatment strategies for mucositis should include relapse and survival endpoints and that pretransplant factors, such as <jats:italic>FEV<\/jats:italic><jats:sub>1<\/jats:sub> and DLCO may be useful to risk\u2010stratify patients entered onto such trials.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06323.x","type":"journal-article","created":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T13:15:16Z","timestamp":1158930916000},"page":"374-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Severe mucositis is associated with reduced survival after autologous stem cell transplantation for lymphoid malignancies"],"prefix":"10.1111","volume":"135","author":[{"given":"S. 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