{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:05:09Z","timestamp":1790186709342,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,10,13]],"date-time":"2006-10-13T00:00:00Z","timestamp":1160697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    An increased iron store has been linked to the risk of atherosclerosis. The carotid intima\u2010media thickness (IMT), stiffness index, Young's elastic modulus (YEM), and augmentation index were determined in 20 patients with beta\u2010thalassaemia major. Compared with controls, patients had greater IMT (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030\u00b7001), YEM (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030\u00b7005), and stiffness (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030\u00b7009) and augmentation (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030\u00b703) indices. The odds ratio for increased IMT in patients was 39. Carotid IMT correlated with YEM (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030\u00b7036), stiffness index (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030\u00b7036) and augmentation index (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030\u00b7006). Multivariate analysis identified patient status (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030\u00b7001) as the only significant determinant of IMT. These findings suggest the possibility of premature atherosclerosis in beta\u2010thalassaemia major patients.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06349.x","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T12:28:27Z","timestamp":1162470507000},"page":"732-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Carotid intima\u2010media thickness is increased and related to arterial stiffening in patients with beta\u2010thalassaemia major"],"prefix":"10.1111","volume":"135","author":[{"given":"Y. F.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0224"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000037225.92759.A7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-3-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131515.03336.f8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10454"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.1.e16"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000178834.26353.d5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1998.00370.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048892.83521.58"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1182\/blood.V92.10.3936","article-title":"Oxidative modification of low\u2010density lipoprotein and atherogenetic risk in \u03b2\u2010thalassemia","volume":"92","author":"Livrea M.A.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.1.2"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1202-799"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06349.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06349.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T17:06:21Z","timestamp":1697389581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06349.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06349.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06349.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"2006-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}