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This study aimed to determine whether sickle\u2010cell trait women had quantitative differences of cf\u2010DNA to controls and if there was an ethnic difference between the cf\u2010DNA levels of Northern European and African\/African\u2010Caribbean populations. Non\u2010invasive prenatal diagnosis, through quantification of fetal and total cf\u2010DNA, was tested in 33 pregnant women at risk of carrying a fetus affected with sickle\u2010cell disease and 124 control pregnancies. A significant variation in cf\u2010DNA was found between ethnic groups, which should be taken into consideration in future studies measuring cf\u2010DNA.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06357.x","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T17:28:27Z","timestamp":1162488507000},"page":"738-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cell\u2010free DNA levels in pregnancies at risk of sickle\u2010cell disease and significant ethnic variation"],"prefix":"10.1111","volume":"135","author":[{"given":"Ageliki","family":"Gerovassili","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kypros H.","family":"Nicolaides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swee Lay","family":"Thein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.6.556"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0713"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000213536"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02344.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02174-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/301800"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.10.1747"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/clinchem\/46.3.319","article-title":"Plasma DNA as a prognostic marker in trauma patients","volume":"46","author":"Lo Y.M.","year":"2000","journal-title":"Clinical Chemistry"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.4.562"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00439-002-0853-9","article-title":"Maternal serum cell\u2010free fetal DNA levels are increased in cases of trisomy 13 but not trisomy 18","volume":"112","author":"Wataganara T.","year":"2003","journal-title":"Human Genetics"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200010)20:10<795::AID-PD897>3.0.CO;2-P"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.051235"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06357.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06357.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:06:35Z","timestamp":1697403995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06357.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06357.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06357.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"2006-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}