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Accumulating genetic and functional evidence points to <jats:italic>ETV6<\/jats:italic> as being the most probable TSG targeted by the deletions. ETV6 is a ubiquitously expressed transcription factor of the ETS family with very few known targets. To understand its function and to elucidate the impact of its absence in leukaemia, we conducted a study to identify targeted genes. Following the induction of <jats:italic>ETV6<\/jats:italic> expression, global expression was evaluated at different time points. We identified 87 modulated genes, of which 10 (<jats:italic>AKR1C1<\/jats:italic>, <jats:italic>AKR1C3<\/jats:italic>, <jats:italic>IL18<\/jats:italic>, <jats:italic>LUM<\/jats:italic>, <jats:italic>PHLDA1<\/jats:italic>, <jats:italic>PTGER4<\/jats:italic>, <jats:italic>PTGS2<\/jats:italic>, <jats:italic>SPHK1<\/jats:italic>, <jats:italic>TP53<\/jats:italic> and <jats:italic>VEGF<\/jats:italic>) were validated by real\u2010time quantitative reverse transcription\u2010polymerase chain reaction. To assess the significance of the validated candidate genes in leukaemia, their expression patterns were determined, as well as that of <jats:italic>ETV6<\/jats:italic>, in pre\u2010B ALL patients. The expression of <jats:italic>IL18<\/jats:italic>, <jats:italic>LUM<\/jats:italic>, <jats:italic>PTGER4<\/jats:italic>, <jats:italic>SPHK1<\/jats:italic> and <jats:italic>TP53<\/jats:italic> was significantly correlated with that of ETV6, further suggesting that ETV6 could regulate the expression of these genes in leukaemia. This work constitutes another step towards the understanding of the functions of ETV6 and the impact of its inactivation in childhood leukaemia.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06377.x","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T11:40:43Z","timestamp":1161949243000},"page":"48-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Identification of transcripts modulated by ETV6 expression"],"prefix":"10.1111","volume":"136","author":[{"given":"Gino","family":"Boily","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Larose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Langlois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sinnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00449-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199909050948"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-200203001-00005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3663180.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5685"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.2953"},{"key":"e_1_2_7_8_1","volume-title":"Functionnal Characterization of ETV6, a Candidate Tumor Suppressor Gene Associated with Acute Lymphoblastic Leukemia. 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