{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:19:24Z","timestamp":1791267564541,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T00:00:00Z","timestamp":1163376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Waldenstr\u00f6m macroglobulinaemia (WM) malignant cells have been considered incapable of undergoing class switch recombination (CSR). However, we report a WM patient who developed an IgG M\u2010component 4\u2003years after diagnosis. When the second monoclonal component appeared, reverse transcription\u2010polymerase chain reaction showed the presence of pre (C<jats:italic>\u03bc<\/jats:italic>) and postswitch (C<jats:italic>\u03b3<\/jats:italic>) clonotypic isotypes; sequencing of these isotypes demonstrated that both corresponded to the single clone amplified at diagnosis, including the same complementarity\u2010determining region 3 and somatic mutation pattern. This proves that WM cells can undergo a functional <jats:italic>in vivo<\/jats:italic> CSR.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06397.x","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T20:06:40Z","timestamp":1163621200000},"page":"114-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Functional class switch recombination may occur \u2018<i>in vivo<\/i>\u2019 in Waldenstr\u00f6m macroglobulinaemia"],"prefix":"10.1111","volume":"136","author":[{"given":"Patricia","family":"Mart\u00edn\u2010Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Garc\u00eda\u2010Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E.","family":"Sarasquete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Ocio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J.","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas F.","family":"San Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.3.1023"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403135"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01971.x"},{"key":"e_1_2_6_5_1","first-page":"905","article-title":"Molecular characteristics and gene segment usage in IGH gene rearrangements in multiple myeloma","volume":"90","author":"Gonzalez D.","year":"2005","journal-title":"Haematologica\/The Hematology journal"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-4024"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3613"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02672-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2005.n.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.3.1070.415k25_1070_1076"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1182\/blood.V100.4.1505.h81602001505_1505_1507","article-title":"Typical Waldenstrom macroglobulinemia is derived from a B\u2010cell arrested after cessation of somatic mutation but prior to isotype switch events","volume":"100","author":"Sahota S.S.","year":"2002","journal-title":"Blood"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50074"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06397.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06397.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:44:15Z","timestamp":1697427855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06397.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,13]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06397.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06397.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,13]]},"assertion":[{"value":"2006-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}