{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T03:25:39Z","timestamp":1764732339965},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:00:00Z","timestamp":1163635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Three <jats:italic>NUP98<\/jats:italic> chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T\u2010ALL): <jats:italic>NUP98\/ADD3<\/jats:italic>, <jats:italic>NUP98\/CCDC28A<\/jats:italic>, and <jats:italic>NUP98\/RAP1GDS1<\/jats:italic>. We report a T\u2010ALL with t(11;18)(p15;q12) resulting in a novel <jats:italic>NUP98<\/jats:italic> fusion. Fluorescent <jats:italic>in situ<\/jats:italic> hybridisation showed <jats:italic>NUP98<\/jats:italic> and SET binding protein 1(<jats:italic>SETBP1<\/jats:italic>) fusion signals; other analyses showed that exon 12 of <jats:italic>NUP98<\/jats:italic> was fused in\u2010frame with exon 5 of <jats:italic>SETBP1<\/jats:italic>. Nested polymerase chain reaction did not amplify the reciprocal <jats:italic>SETBP1\/NUP98<\/jats:italic>, suggesting that <jats:italic>NUP98\/SETBP1<\/jats:italic> transcript is pathogenetically important. <jats:italic>SETBP1<\/jats:italic> has previously not been implicated in leukaemias; however, it encodes a protein that specifically interacts with SET, fused to NUP214 in a case of acute undifferentiated leukaemia.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06410.x","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T13:50:52Z","timestamp":1163685052000},"page":"294-296","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Fusion of <i>NUP98<\/i> and the SET binding protein 1 (<i>SETBP1<\/i>) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12)"],"prefix":"10.1111","volume":"136","author":[{"given":"Ioannis","family":"Panagopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitte","family":"Kerndrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Carlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil","family":"Str\u00f6mbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareth","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,16]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.2072"},{"key":"e_1_2_3_3_1","first-page":"3079","article-title":"NUP98 is fused to adducin 3 in a patient with T\u2010cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15)","volume":"63","author":"Lahortiga I.","year":"2003","journal-title":"Cancer Research"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050309"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02106.x"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02000.x"},{"key":"e_1_2_3_7_1","volume-title":"Mitelman database of chromosome aberrations in cancer","author":"Mitelman F.","year":"2006"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404130"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10461"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001659325"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2006.06410.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2006.06410.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T20:56:07Z","timestamp":1697403367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2006.06410.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,16]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2141.2006.06410.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06410.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,16]]},"assertion":[{"value":"2006-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}