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B\u2010cell activating factor (BAFF) is a member of the tumour necrosis factor family and an important regulator of B\u2010cell development. BAFF levels were determined in serum samples from 53 patients with ITP. Serum BAFF levels in patients with an active ITP were increased when compared with the healthy control group (median 1620\u2003pg\/ml vs. 977\u2003pg\/ml; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001). Moreover, immunosuppressive treatment was associated with strongly suppressed BAFF levels (median 629\u2003pg\/ml; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b701). In addition, a polymorphic site was detected in the <jats:italic>BAFF<\/jats:italic> promoter region (\u2212871) that appeared to occur more frequently in ITP patients than in healthy persons. This promoter variant was associated with very high BAFF levels in ITP patients. Our data suggest that BAFF is an important pathogenetic factor in the development of ITP.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06431.x","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T09:20:14Z","timestamp":1164878414000},"page":"309-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["High\u2010level serum B\u2010cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura"],"prefix":"10.1111","volume":"136","author":[{"given":"Florian","family":"Emmerich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcrkan","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Milz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"M\u00fchle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Martinez\u2010Gamboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"D\u00f6rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulgabar","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5234.286"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.02.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.4.1165.1165"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1182\/blood.V74.7.2309.2309","article-title":"Therapy 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