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We investigated whether activation of canonical Wnt signalling could occur in B\u2010ALL cells and thereby play a potential role in cellular growth and\/or survival. This study found that Wnt3A induced <jats:italic>\u03b2<\/jats:italic>\u2010catenin accumulation in both primary B\u2010ALL cells and B\u2010ALL leukaemia cell lines. Further, Wnt3A was shown to induce nuclear translocation of <jats:italic>\u03b2<\/jats:italic>\u2010catenin and TCF\/Lef\u20101 dependent transcriptions in the B\u2010ALL cell line Nalm\u20106. Examination of the mRNA expression pattern of <jats:italic>WNT<\/jats:italic> ligands, <jats:italic>FZD<\/jats:italic> receptors and <jats:italic>WNT<\/jats:italic> antagonists in Nalm\u20106 cells identified a set of ligands and receptors available for signalling, as well as antagonists potentially available for modulating the response. Functional analyses showed that Wnt3A inhibited the proliferation of several, but not all, B\u2010ALL cell lines studied. Finally, microarray analysis was used to identify several Wnt3A target genes involved in a diverse range of cellular activities, which are potential mediators of the Wnt3A\u2010restrained proliferation.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2006.06442.x","type":"journal-article","created":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T12:32:32Z","timestamp":1165581152000},"page":"400-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Wnt3A activates canonical Wnt signalling in acute lymphoblastic leukaemia (ALL) cells and inhibits the proliferation of B\u2010ALL cell lines"],"prefix":"10.1111","volume":"136","author":[{"given":"Marit Kveine","family":"Nygren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guri","family":"D\u00f8sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit 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