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The most common histological subtypes are diffuse large B\u2010cell and marginal zone B\u2010cell NHL of the mucosa\u2010associated lymphoid tissue (MALT)\u2010type. Pathogenesis is often related to <jats:italic>Helicobacter pylori<\/jats:italic> infection (HPI). There is still no consensus on the optimal treatment for PG lymphoma. Nowadays surgery is limited to rare cases and radiotherapy \u2013 combined or not with chemotherapy \u2013 represents an effective therapeutic option ensuring long\u2010term, organ\u2010salvage benefits mainly in aggressive histological subtypes. Additionally, the description of MALT lymphomas has made the situation even more complex, because antibiotics alone can induce lasting remissions in those cases associated with HPI. 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