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Many of the symptoms of PNH, including recurrent abdominal pain, dysphagia, severe lethargy and erectile dysfunction, result from intravascular haemolysis with absorption of nitric oxide by free haemoglobin from the plasma. These symptoms, as well as the occurrence of thrombosis and aplasia, significantly affect patients\u2019 quality of life; thrombosis is the leading cause of premature mortality. The syndrome of haemolytic\u2010anaemia\u2010associated pulmonary hypertension has been further identified in PNH patients. 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