{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:01:44Z","timestamp":1761919304901},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T00:00:00Z","timestamp":1263340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The presence of a dicentric chromosome dic(9;20) has been reported to have an unfavourable prognosis in children with B\u2010cell precursor acute lymphoblastic leukaemia (BCP\u2010ALL). As outcome may be influenced by type and composition of treatment, we analyzed 19 BCP\u2010ALL patients with dic(9;20) who have been treated with ALL\u2010BFM (Berlin\u2010Frankfurt\u2010M\u00fcnster) protocols that included a 4\u2010drug induction and subsequent consolidation therapy. All patients were good responders to prednisone and in complete remission after induction therapy. Eight patients had no molecular disease after induction and another eight patients had levels \u226410<jats:sup>\u22124<\/jats:sup> after consolidation therapy. After a median follow\u2010up of 3\u00b74\u2003years, probabilities of 5\u2010year event\u2010free and overall survival were 75\u2003\u00b1\u200311% and 94\u2003\u00b1\u20036%, respectively. Of note, there was a tendency for extramedullary disease in case of relapse (two of three relapses with central nervous system involvement). In conclusion, in the context of ALL\u2010BFM protocols dic(9;20)\u2010positivity appeared to have a favourable prognosis, which could be due to a dose\u2010 and time\u2010intensified induction and induction consolidation therapy. Given that <jats:italic>in vitro<\/jats:italic> studies have shown high cellular sensitivity of dic(9;20)\u2010positive leukemic blasts to <jats:sc>l<\/jats:sc>\u2010asparaginase and cytarabine, it is reasonable to speculate that both drugs, as given early during BFM\u2010like induction and consolidation therapy, may have contributed to this good outcome.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2009.08059.x","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T06:15:25Z","timestamp":1263363325000},"page":"93-100","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic relevance of dic(9;20)(p11;q13) in childhood B\u2010cell precursor acute lymphoblastic leukaemia treated with Berlin\u2010Frankfurt\u2010M\u00fcnster (BFM) protocols containing an intensive induction and post\u2010induction consolidation 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