{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:14:31Z","timestamp":1782969271139,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>FOXP2<\/jats:italic> mutation causes a severe inherited speech and language defect, while the related transcription factors FOXP1, FOXP3 and FOXP4 are implicated in cancer. <jats:italic>FOXP2<\/jats:italic> mRNA and protein expression were characterised in normal human tissues, haematological cell lines and multiple myeloma (MM) patients\u2019 samples. <jats:italic>FOXP2<\/jats:italic> mRNA and protein were absent in mononuclear cells from different anatomical sites, lineages and stages of differentiation. However, <jats:italic>FOXP2<\/jats:italic> mRNA and protein was detected in several lymphoma (8\/20) and all MM\u2010derived cell lines (<jats:italic>n<\/jats:italic>\u2003=\u20034). <jats:italic>FOXP2<\/jats:italic> mRNA was expressed in bone marrow samples from 96% of MM patients (24\/25), 66\u00b77% of patients with the pre\u2010neoplastic plasma cell proliferation monoclonal gammopathy of undetermined significance (MGUS) (6\/9), but not in reactive plasma cells. The frequency of FOXP2 protein expression in CD138<jats:sup>+<\/jats:sup> plasma cells was significantly higher in MGUS (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b70005; mean 46\u00b74%) and MM patients (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030\u00b70001; mean 57\u00b73%) than in reactive marrows (mean 2\u00b75%). FOXP2 (&gt;10% nuclear positivity) was detectable in 90\u00b72% of MM (55\/61) and 90\u00b79% of MGUS (10\/11) patients, showing more frequent expression than CD56 and labelling 75% of CD56\u2010negative MM (9\/12). FOXP2 represents the first transcription factor whose expression consistently differentiates normal and abnormal plasma cells and FOXP2 target genes are implicated in MM pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2009.08070.x","type":"journal-article","created":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T02:48:18Z","timestamp":1264042098000},"page":"221-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Aberrant expression of the neuronal transcription factor <i>FOXP2<\/i> in neoplastic plasma cells"],"prefix":"10.1111","volume":"149","author":[{"given":"Andrew J.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linden","family":"Lyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip 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