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CD19\u2010L is the first CD19\u2010specific recombinant human protein with potent anti\u2010leukaemic activity against B\u2010lineage acute lymphoblastic leukaemia (ALL), the most common form of childhood cancer and the second most common form of acute leukaemia in adults. Soluble recombinant CD19\u2010L protein exhibited exquisite specificity for the extracellular domain of CD19 and strong binding to the surface of B\u2010lineage leukaemia\/lymphoma cells. Engagement of CD19 co\u2010receptor on B\u2010lineage ALL cells with CD19\u2010L perturbed the CD19\u2010associated signalling network, altering the expression levels of multiple genes directly involved in regulation of apoptosis, and triggered rapid apoptotic cell death in a CD19\u2010specific manner. The identification of human CD19\u2010L may lead to therapeutic innovation for B\u2010lineage ALL and other B\u2010lineage lymphoid malignancies as well as B\u2010cell lymphoproliferative states and systemic autoimmunity.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.08583.x","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T06:08:37Z","timestamp":1297922917000},"page":"15-23","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Recombinant human CD19\u2010ligand protein as a potent anti\u2010leukaemic agent"],"prefix":"10.1111","volume":"153","author":[{"given":"Fatih M.","family":"Uckun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjive","family":"Qazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahide","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071944"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260936"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70229-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1373518"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.4049\/jimmunol.154.7.3096","article-title":"B\u2010cell antigen receptor mediated apoptosis. 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