{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:29:34Z","timestamp":1788280174874,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T00:00:00Z","timestamp":1298160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:sc>l<\/jats:sc>\n                    \u2010asparaginase encapsulated within erythrocytes (GRASPA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) should allow serum asparagine depletion over a longer period than the native form of the enzyme, using lower doses and allowing better tolerance. The GRASPALL 2005\u201001 study, a multicentre randomized controlled trial, investigated three doses of GRASPA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    for the duration of asparagine depletion in a phase I\/II study in adults and children with acute lymphoblastic leukaemia (ALL) in first relapse. Between February 2006 and April 2008, 18 patients received GRASPA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    (50\u2003iu\/kg:\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u20036, 100\u2003iu\/kg:\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u20036, 150\u2003iu\/kg:\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u20036) after randomization, and six patients were assigned to the\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    native\n                    <jats:sc>l<\/jats:sc>\n                    \u2010asparaginase (\n                    <jats:italic>E.\u00a0coli<\/jats:italic>\n                    <jats:sc>l<\/jats:sc>\n                    \u2010ASNase) control group. GRASPA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    was effective at depleting\n                    <jats:sc>l<\/jats:sc>\n                    \u2010asparagine. One single injection of 150\u2003iu\/kg of GRASPA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    provided similar results to 8\u2003\u00d7\u200310\u2003000\u2003iu\/m\n                    <jats:sup>2<\/jats:sup>\n                    intravenous injections of\n                    <jats:italic>E.\u00a0coli<\/jats:italic>\n                    <jats:sc>l<\/jats:sc>\n                    \u2010ASNase. The safety profile of GRASPA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    showed a reduction in the number and severity of allergic reactions and a trend towards less coagulation disorders. Other expected adverse events were comparable to those observed with\n                    <jats:italic>E.\u00a0coli<\/jats:italic>\n                    <jats:sc>l<\/jats:sc>\n                    \u2010ASNase and there was also no difference between the three doses of GRASPA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.08588.x","type":"journal-article","created":{"date-parts":[[2011,2,21]],"date-time":"2011-02-21T00:02:02Z","timestamp":1298246522000},"page":"58-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["<scp>l<\/scp>\n                    \u2010asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005\u201001 randomized 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