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The resistance of B\u2010lineage ALL cells to the standard anti\u2010leukaemic drug vincristine was overcome by the HSPA5 inhibitor epigallocatechin gallate, which inhibits the anti\u2010apoptotic function of HSPA5 by targeting its ATP\u2010binding domain. Notably, chemotherapy\u2010resistant B\u2010lineage ALL cells underwent apoptosis within 48\u2003h of exposure to a doxorubicin\u2010conjugated cell\u2010penetrating cyclic anti\u2010HSPA5 peptide targeting surface\u2010expressed HSPA5 molecules on leukaemia cells. The identification of the HSPA5 as a chemoresistance biomarker and molecular target for B\u2010lineage ALL may lead to new anti\u2010leukaemic treatment strategies that are much needed.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.08671.x","type":"journal-article","created":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T11:17:25Z","timestamp":1303730245000},"page":"741-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Inducing apoptosis in chemotherapy\u2010resistant B\u2010lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti\u2010apoptotic unfolded protein response signalling network"],"prefix":"10.1111","volume":"153","author":[{"given":"Fatih 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