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Until recently, the two only main options for patients with PNH were either allogeneic bone marrow transplantation or supportive management, including blood transfusion: both options require some skill and good patient\u2010doctor collaboration. Since the start of this millennium a major advance has been the introduction of eculizumab, a monoclonal antibody that targets the C5 protein of the complement system: blockade of C5 prevents activation of the complement distal pathway, and thus abrogates the complement\u2010mediated intravascular haemolysis that severely plagues patients with PNH. This review outlines an approach to the management of all three major components of the clinical picture of PNH \u2013 namely haemolysis, thrombosis and bone marrow failure \u2013 based on the literature and on personal experience. We consider specifically how the use of eculizumab has modified other aspects of the management of PNH, and even the pathophysiology itself of this disease. Finally, we develop a treatment algorithm which others might find helpful.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.08690.x","type":"journal-article","created":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T10:38:05Z","timestamp":1303468685000},"page":"709-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Management of Paroxysmal Nocturnal Haemoglobinuria: a personal 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