{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:11:43Z","timestamp":1790932303625,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T00:00:00Z","timestamp":1305158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Resistance to activated protein C (aPC) is most commonly due to the <jats:italic>F5<\/jats:italic> rs6025 (factor V Leiden) polymorphism, which increases the risk of venous thrombosis. In the present population\u2010based study of 313 cases and 353 controls, we investigated whether reduced sensitivity to aPC was associated with a history of pregnancy\u2010related venous thrombosis. Calibrated automated thrombography was used to determine the sensitivity to aPC, and normalized aPC sensitivity ratio (n\u2010aPC\u2010sr) was calculated. Pregnant women and women using oral contraceptives and\/or anticoagulants were excluded due to the effect on the n\u2010aPC\u2010sr. In women without the <jats:italic>F5<\/jats:italic> rs6025 polymorphism, free tissue factor pathway inhibitor (TFPI), free protein S and protein C activity were associated with n\u2010aPC\u2010sr. Unadjusted odds ratio for venous thrombosis for women with n\u2010aPC\u2010sr in the 4th quartile as compared with n\u2010aPC\u2010sr below the 4th quartile was 2\u00b74 (95% confidence interval 1\u00b77\u20133\u00b76). Adjusting for free protein S, free TFPI and age did not influence the odds ratios. Also in carriers of the <jats:italic>F5<\/jats:italic> rs6025 polymorphism the risk for venous thrombosis was increased for women with higher n\u2010aPC\u2010sr. Our findings substantiate the importance of the aPC resistant phenotype as a risk factor for pregnancy\u2010related venous thrombosis.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.08712.x","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T12:13:13Z","timestamp":1305202393000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Resistance to activated protein C is a risk factor for pregnancy\u2010related venous thrombosis in the absence of the <i>F5<\/i> rs6025 (factor V Leiden) polymorphism"],"prefix":"10.1111","volume":"154","author":[{"given":"Astrid","family":"Bergrem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Erik Astrup","family":"Dahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Flem","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Mowinckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiv","family":"Sandvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Morten","family":"Sandset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2001.00421.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.12.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03117.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1055\/s-0037-1616135","article-title":"Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous thrombosis","volume":"86","author":"Castaman G.","year":"2001","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(11)70007-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.4.1135"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000168421.13467.82"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3188"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504240103"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00691-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00111-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071636"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(95)90011-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1182\/blood.V86.5.1794.bloodjournal8651794","article-title":"Factors IXa and Xa play distinct roles in tissue factor\u2010dependent initiation of coagulation","volume":"86","author":"Hoffman M.","year":"1995","journal-title":"Blood"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03111.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02961.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32830f1b85"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0343"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91803-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-8-199904200-00004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70699-X"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996021"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04443.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1055\/s-0038-1657642","article-title":"The VITA project: phenotypic resistance to activated protein C and FV Leiden mutation in the general population. 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