{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:02:28Z","timestamp":1779919348236,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T00:00:00Z","timestamp":1316390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Children with chromosomal instability syndromes have an increased risk of developing lymphoma and leukaemia. The treatment of these malignancies is hampered by therapy\u2010associated toxicity and infectious complications. This retrospective analysis evaluated the therapy outcome of 38 children with Ataxia teleangiectasia or Nijmegen\u2010breakage syndrome with acute lymphoblastic leukaemia (ALL, <jats:italic>n<\/jats:italic>\u2003=\u20039), Non\u2010Hodgkin lymphoma (NHL, <jats:italic>n<\/jats:italic>\u2003=\u200328) and Hodgkin lymphoma (HL, <jats:italic>n<\/jats:italic>\u2003=\u20031). All patients with NHL or ALL were treated in accordance to Berlin\u2010Frankfurt\u2010M\u00fcnster (BFM)\u2010 or Co\u2010operative study group for childhood ALL (CoALL)\u2010oriented chemotherapy schedules. 22 patients received significantly reduced\u2010intensity chemotherapy. After a median follow\u2010up of 3\u00b77\u2003years the 10\u2010year overall survival was 58%. Dosage\u2010reduction of chemotherapeutic drugs seemed to have no disadvantages and reduced toxic side effects. On the other hand, reduced\u2010intensity chemotherapy did not prevent second malignancies, which occurred in ten patients with a 10\u2010year incidence of 25%. After individual treatment approaches three of these patients with second malignancies were in complete clinical remission for more than 5\u2003years. We conclude that BFM\u2010 or CoALL\u2010oriented chemotherapy is effective and can be administered in children with AT or NBS. Moreover, we show that even second lymphoid malignancies can successfully be treated in these patients.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.08863.x","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T10:24:53Z","timestamp":1316427893000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Promising therapy results for lymphoid malignancies in children with chromosomal breakage syndromes (Ataxia teleangiectasia or Nijmegen\u2010breakage syndrome): a retrospective survey"],"prefix":"10.1111","volume":"155","author":[{"given":"Klaus","family":"Bienemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Modlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"M\u00f6ricke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Bienemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mauz\u2010K\u00f6rholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Escherich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"K\u00f6rholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gritta","family":"Janka\u2010Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schrappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. 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