{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:02:10Z","timestamp":1790560930643,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T00:00:00Z","timestamp":1319414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The long\u2010term antibody responses to re\u2010immunization in recipients of allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) have not been well studied. We prospectively and longitudinally evaluated the antibody responses to eight vaccine antigens (diphtheria, tetanus, pertussis, measles, mumps, rubella, hepatitis B, and poliovirus) and assessed the factors associated with negative titres in 210 allo\u2010HSCT recipients at St. Jude Children\u2019s Research Hospital. Antibody responses lasting for more than 5\u2003years after immunization were observed in most patients for tetanus (95\u00b77%), rubella (92\u00b73%), poliovirus (97\u00b79%), and, in diphtheria\u2010tetanus\u2010acellular pertussis (DTaP) recipients, diphtheria (100%). However, responses to pertussis (25\u00b70%), measles (66\u00b77%), mumps (61\u00b75%), hepatitis B (72\u00b79%), and diphtheria in tetanus\u2010diphtheria (Td) recipients (48\u00b76%) were less favourable, with either only transient antibody responses or persistently negative titres. Factors associated with vaccine failure were older age at immunization; lower CD3, CD4 or CD19 counts; higher IgM concentrations; positive recipient cytomegalovirus serology; negative titres before immunization; acute or chronic graft\u2010<jats:italic>versus<\/jats:italic>\u2010host disease; and radiation during preconditioning. These response patterns and clinical factors can be used to formulate re\u2010immunization and monitoring strategies. Patients at risk for vaccine failure should have long\u2010term follow\u2010up; those with loss of antibody response or no seroconversion should receive booster immunizations.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.08913.x","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T07:57:35Z","timestamp":1319443055000},"page":"109-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Longitudinal analysis of antibody response to immunization in paediatric survivors after allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"156","author":[{"given":"Hiroto","family":"Inaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine 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