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Translocations are present in some patients and affect regions recurrently involved in CLL. This report describes the clinical and pathological characteristics of four CLL patients showing a new recurrent chromosomal abnormality dic(8;17)(p11;p11), that implied loss of the <jats:italic>TP53<\/jats:italic> gene in all cases. In addition, <jats:italic>TP53<\/jats:italic> gene was mutated in three out of four patients. Mechanically, Low Copy Repeats (LCR) in 17p12 and 8p11 may explain the origin of the translocation by non\u2010allelic homologous recombination (NAHR). Isolated dic(8;17)(p11;p11) in patients with mutated <jats:italic>IGHV<\/jats:italic> genes status may not have the same prognostic impact as other mutations or deletions affecting the <jats:italic>TP53<\/jats:italic> gene. Larger series are needed to better evaluate the clinical impact of this chromosomal aberration during the course of the disease.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.08978.x","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T07:11:21Z","timestamp":1323414681000},"page":"612-618","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A new genetic abnormality leading to <i>TP53<\/i> gene deletion in chronic lymphocytic 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