{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:31:30Z","timestamp":1791153090990,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The World Health Organization classification uses a cut\u2010off point of 5\u00b70\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/l cells with a chronic lymphocytic leukaemia (CLL)\u2010phenotype in peripheral blood to discriminate between monoclonal B\u2010lymphocytosis (MBL) and B\u2010CLL. This study analysed 298 MBL patients by multi\u2010parameter flow cytometry, chromosome banding analysis (CBA)\/fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH), and <jats:italic>IGHV<\/jats:italic> mutation status and compared them with 356 CLL patients. In MBL, CBA more frequently revealed a normal karyotype and FISH identified less frequently del(6q), del(13q) (as sole alterations), and del(17)(p13). Within the MBL cohort, a shorter time to treatment (TTT) was found for ZAP\u201070\u2010positivity, 14q32\/<jats:italic>IGH\u2010<\/jats:italic>translocations (CBA), del(11)(q22\u00b73) (FISH) and unmutated <jats:italic>IGHV<\/jats:italic> status. Higher CD38 and ZAP\u201070 expression, del(11)(q22\u00b73) (FISH), trisomy 12 (FISH), and 14q32\/<jats:italic>IGH\u2010<\/jats:italic>translocations (CBA) were correlated with a shorter TTT in the combined cohort (MBL\u2003+\u2003CLL); a sole del(13)(q14) (FISH) correlated with longer TTT. Regarding overall survival, unmutated <jats:italic>IGHV<\/jats:italic> status and \u2018other\u2019 alterations (CBA) had an adverse impact. There was no correlation between the concentration of CLL\u2010cells and TTT or overall survival. Multivariate analysis confirmed a negative impact on TTT for del(11)(q22\u00b73)\/<jats:italic>ATM<\/jats:italic>, trisomy 12 (both by FISH), and 14q32\/<jats:italic>IGH\u2010<\/jats:italic>translocations by CBA. These data emphasize a close relationship between MBL and CLL regarding clinically relevant parameters and provide no evidence to strictly separate these entities by a distinct threshold of clonal B\u2010cells.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2011.09010.x","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T07:46:55Z","timestamp":1326095215000},"page":"86-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Monoclonal B\u2010cell lymphocytosis is closely related to chronic lymphocytic leukaemia and may be better classified as early\u2010stage CLL"],"prefix":"10.1111","volume":"157","author":[{"given":"Wolfgang","family":"Kern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Bacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Dicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Alpermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Schnittger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.305"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4393"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-176933"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-005322"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432602"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-357251"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(99)00095-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1801"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404457"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-074-4_9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404935"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-093906"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20483"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1410.h81602001410_1410_1416"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.60"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.192"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.117"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806122"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06865.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.030189"},{"key":"e_1_2_7_22_1","first-page":"180","volume-title":"Chronic Lymphocytic Leukemia\/Small Lymphocytic Leukemia. 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