{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:15:04Z","timestamp":1783372504029,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T00:00:00Z","timestamp":1328659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"Summary<\/jats:title>Burkitt lymphoma (BL<\/jats:styled-content>) was first described in U<\/jats:styled-content>ganda in 1958 as a sarcoma of the jaw but later confirmed to be a distinct form of N<\/jats:styled-content>on H<\/jats:styled-content>odgkin lymphoma (NHL<\/jats:styled-content>). This discovery was the defining moment of cancer research in Uganda, which eventually led to the establishment of a dedicated cancer research institute, the U<\/jats:styled-content>ganda C<\/jats:styled-content>ancer Institute (UCI<\/jats:styled-content>) in 1967. The centre was dedicated to D<\/jats:styled-content>enis B<\/jats:styled-content>urkitt in recognition of his contribution to cancer research in E<\/jats:styled-content>ast A<\/jats:styled-content>frica. BL<\/jats:styled-content> is still the commonest NHL<\/jats:styled-content> in childhood in U<\/jats:styled-content>ganda. Its incidence has significantly increased recently due to yet unknown factors. Although the human immunodeficiency virus (HIV<\/jats:styled-content>) was considered a possible reason for the increase, there is no evidence that it has substantially impacted on the epidemiology of the disease. However, for those patients with BL<\/jats:styled-content> who are co infected with HIV<\/jats:styled-content> there is a clear impact of the disease on clinical presentation and outcome. HIV<\/jats:styled-content>\u2010infected patients commonly present with extra facial sites and tend to have poor overall survival (median survival of 11\u00b779\u00a0months). In summary, BL<\/jats:styled-content>, as a disease entity in Uganda, has maintained the same clinical characteristics since its discovery, despite the emergence of HIV<\/jats:styled-content> during the intervening period.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09027.x","type":"journal-article","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T09:51:41Z","timestamp":1328694701000},"page":"757-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Burkitt lymphoma in UGANDA<\/scp>, the legacy of D<\/scp>enis B<\/scp>urkitt and an update on the disease status"],"prefix":"10.1111","volume":"156","author":[{"given":"Victoria","family":"Walusansa","sequence":"first","affiliation":[{"name":"Uganda Cancer Institute Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Okuku","sequence":"additional","affiliation":[{"name":"Uganda Cancer Institute Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Orem","sequence":"additional","affiliation":[{"name":"Uganda Cancer Institute Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619704"},{"key":"e_1_2_7_3_1","first-page":"511","article-title":"Observations on the geography of malignant lymphoma","volume":"38","author":"Burkitt D.P.","year":"1961","journal-title":"East African Medical Journal"},{"key":"e_1_2_7_4_1","first-page":"211","article-title":"A lymphoma syndrome in African children","volume":"30","author":"Burkitt D.","year":"1962","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196504)18:4<399::AID-CNCR2820180402>3.0.CO;2-G"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbm.1995.0006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200013"},{"issue":"9","key":"e_1_2_7_8_1","first-page":"S135","article-title":"Clinical characteristics of Burkitt's lymphoma from three regions in Kenya","volume":"82","author":"Mwanda W.O.","year":"2005","journal-title":"East African Medical Journal"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225472"},{"key":"e_1_2_7_10_1","first-page":"543","article-title":"Etiology of endemic Kaposi's sarcoma","volume":"63","author":"Olweny C.L.","year":"1984","journal-title":"IARC Scientific Publications"},{"key":"e_1_2_7_11_1","first-page":"89","article-title":"Etiology of hepatocellular carcinoma in Africa","volume":"63","author":"Olweny C.L.","year":"1984","journal-title":"IARC Scientific Publications"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc073375"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197510)36:4<1250::AID-CNCR2820360410>3.0.CO;2-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<787::AID-CNCR2820420251>3.0.CO;2-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801215)46:12<2717::AID-CNCR2820461230>3.0.CO;2-T"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000259258"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200409000-00010"},{"issue":"9","key":"e_1_2_7_18_1","first-page":"S144","article-title":"Oral combination chemotherapy in the treatment of AIDS\u2010associated Hodgkin's disease","volume":"82","author":"Orem J.","year":"2005","journal-title":"East African Medical Journal"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2004.10.001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cco.0000239887.90665.10"},{"key":"e_1_2_7_21_1","first-page":"166","article-title":"Burkitt's lymphoma in Africa, a review of the epidemiology and etiology","volume":"7","author":"Orem J.","year":"2007","journal-title":"African Health Science"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1258\/td.2007.060093"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21769"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2011.08.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200012220-00015"},{"issue":"9","key":"e_1_2_7_26_1","first-page":"S155","article-title":"Strategies to overcome myelotoxic therapy for the treatment of Burkitt's and AIDS\u2010related non\u2010Hodgkin's lymphoma","volume":"82","author":"Rochford R.","year":"2005","journal-title":"East African Medical Journal"},{"key":"e_1_2_7_27_1","first-page":"1585","article-title":"Trends in cancer incidence in Kyadondo County, Uganda, 1960\u20131997","volume":"82","author":"Wabinga H.R.","year":"2000","journal-title":"British Journal of Cancer"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2012.09027.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2012.09027.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T12:06:22Z","timestamp":1694606782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2012.09027.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,8]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1365-2141.2012.09027.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09027.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,8]]},"assertion":[{"value":"2011-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}