{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:13:43Z","timestamp":1776780823759,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The pathological background in nodular lymphocyte predominant Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>) consists of lymphocytes and histocytes. This study analysed the peripheral blood absolute lymphocyte count\/absolute monocyte count ratio at diagnosis (<jats:styled-content style=\"fixed-case\">ALC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DX<\/jats:styled-content>) on the impact of survival in<jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>. One hundred and three consecutive<jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>patients that were followed at<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ayo<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linic from 1974 to 2010 were included in the study. Receiver operating characteristic and area under the curve were used for<jats:styled-content style=\"fixed-case\">ALC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DX<\/jats:styled-content>cut\u2010off value analysis and proportional\u2010hazards models were used to compare survival based on the<jats:styled-content style=\"fixed-case\">ALC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DX<\/jats:styled-content>ratio. With a median follow\u2010up of 8\u00b79\u00a0years (range: 0\u00b73\u201331\u00a0years), an<jats:styled-content style=\"fixed-case\">ALC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DX<\/jats:styled-content>\u22652\u00b71 was the best cut\u2010off value for survival with an area under the curve of 0\u00b782, a sensitivity of 70% and specificity of 84%. After adjusting for the<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rognostic<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core (<jats:styled-content style=\"fixed-case\">IPS<\/jats:styled-content>),<jats:styled-content style=\"fixed-case\">ALC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DX<\/jats:styled-content>remained an independent prognostic factor for overall survival [<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>azard<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>atio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>), 0\u00b733, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 0\u00b715\u20130\u00b771%,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7004]; lymphoma\u2010specific survival (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 0\u00b705; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0\u00b701\u20130\u00b768%,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7002); progression\u2010free survival (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 0\u00b730; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0\u00b714\u20130\u00b760%,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7006), and time to progression (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 0\u00b706, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0\u00b704\u20130\u00b730%,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7004).<jats:styled-content style=\"fixed-case\">ALC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DX<\/jats:styled-content>is a low cost, already standarized, biomarker to predict clinical outcomes in<jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09067.x","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T05:57:48Z","timestamp":1330063068000},"page":"321-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Peripheral blood lymphocyte\/monocyte ratio at diagnosis and survival in nodular lymphocyte\u2010predominant<scp>H<\/scp>odgkin lymphoma"],"prefix":"10.1111","volume":"157","author":[{"given":"Luis F.","family":"Porrata","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Ristow","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Witzig","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Colgan","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Inwards","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Ansell","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana N.","family":"Micallef","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick B.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz S.","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetomir N.","family":"Markovic","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24819"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0bO13e31820dbc2c"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820501)49:9<1848::AID-CNCR2820490918>3.0.CO;2-Y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables","volume":"34","author":"Cox D.R.","year":"1972","journal-title":"Journal of the Royal Statistical Society: Series B"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/84.3.297"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.776"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811193392104"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq063"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_7_12_1","first-page":"1137","article-title":"A study of cross\u2010validation and bootstrap for accuracy estimation and model selection","volume":"2","author":"Kohave R.","year":"1995","journal-title":"International Joint Conference on Artificial Intelligence (IJCAI)"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1105656"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0099"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/142395"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.8869"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.050138"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404900"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905680"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903370338"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-220111"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21303"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2012.09067.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2012.09067.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T09:28:55Z","timestamp":1713605335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2012.09067.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1365-2141.2012.09067.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09067.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]},"assertion":[{"value":"2011-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}