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Here we show that the knockdown of MECOM<\/jats:styled-content> (E<\/jats:styled-content>) and MECOM<\/jats:styled-content> (ME<\/jats:styled-content>) isoforms reduces cell division at low cell density, inhibits colony\u2010forming cells by 34% and moderately reduces BCR\u2010ABL1<\/jats:italic><\/jats:styled-content> mRNA<\/jats:styled-content> and protein expression but not tyrosine kinase catalytic activity in K<\/jats:styled-content>562 cells. We also show that both E<\/jats:styled-content><\/jats:italic> and ME<\/jats:styled-content><\/jats:italic> are expressed in CD<\/jats:styled-content>34+<\/jats:sup> selected cells of both CML<\/jats:styled-content> chronic phase (CML<\/jats:styled-content>\u2010CP<\/jats:styled-content>), and non\u2010CML<\/jats:styled-content> (normal) origin. Furthermore, MECOM<\/jats:italic><\/jats:styled-content> mRNA<\/jats:styled-content> and protein expression were repressed by imatinib mesylate treatment of CML<\/jats:styled-content>\u2010CP CD<\/jats:styled-content>34+<\/jats:sup> cells, K<\/jats:styled-content>562 and KY<\/jats:styled-content>01 cell lines whereas imatinib had no effect in non\u2010CML BCR<\/jats:styled-content>\u2010ABL<\/jats:styled-content>1 \u2212ve CD<\/jats:styled-content>34+<\/jats:sup> cells. Together these results suggest that BCR<\/jats:styled-content>\u2010ABL<\/jats:styled-content>1 tyrosine kinase catalytic activity regulates MECOM<\/jats:italic><\/jats:styled-content> gene expression in CML<\/jats:styled-content>\u2010CP<\/jats:styled-content> progenitor cells and that the BCR<\/jats:styled-content>\u2010ABL<\/jats:styled-content>1 oncoprotein partially mediates its biological activity through MECOM<\/jats:styled-content>. MECOM<\/jats:italic><\/jats:styled-content> gene expression in CML<\/jats:styled-content>\u2010CP<\/jats:styled-content> progenitor cells would provide an in vivo<\/jats:italic> selective advantage, contributing to CML<\/jats:styled-content> pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09078.x","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T06:48:34Z","timestamp":1330498114000},"page":"446-456","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["BCR<\/scp>\u2010ABL<\/scp>1 tyrosine kinase sustained MECOM<\/i><\/scp> expression in chronic myeloid leukaemia"],"prefix":"10.1111","volume":"157","author":[{"given":"Swagata","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Life Sciences City Campus Glasgow Caledonian University Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather 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