{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:14:17Z","timestamp":1793150057131,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:00:00Z","timestamp":1330992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Merkel cell carcinoma (<jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>) is a rare aggressive skin tumour that appears to be associated with a large number of other tumours. We collected all reported cases in Israel and estimated its association with other tumours, including haematological malignancies. The population based <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>srael <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ancer <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egistry identified 335 patients with <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> diagnosed between1989 and 2010. Ninety\u2010seven percent were in the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ewish population; median age at diagnosis for <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ewish patients was 73\u00b74 and 55\u00b76\u00a0years for the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rab population. Other associated malignancies were encountered in 92 patients (27\u00b74%) with <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> (90 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ews, two <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rabs). Of the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ewish cases, 66 presented with an associated malignancy before, and 24 after, the diagnosis of <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>. Solid tumours were not significantly increased among patients with <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>. Thirty\u2010one of these associated cancers (34\u00b74%) were haemato\u2010oncological malignancies, 24 were detected before and seven after the diagnosis of <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>. The standardized incidence ratio (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content>) for haematological malignancy was 3\u00b767 for males and 3\u00b762 for females, and the most frequent haemato\u2010oncological neoplasias recorded were chronic lymphocytic leukaemia (45%) and lymphomas (29%). Although <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> is rare, clinicians should be aware of the possible association with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphoproliferative disorders when evaluating patients with neuroendocrine skin tumours.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09087.x","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T07:59:43Z","timestamp":1331020783000},"page":"457-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Increased incidence of chronic lymphocytic leukaemia and lymphomas in patients with <scp>M<\/scp>erkel cell carcinoma \u2013 a population based study of 335 cases with neuroendocrine skin tumour"],"prefix":"10.1111","volume":"157","author":[{"given":"Tamar","family":"Tadmor","sequence":"first","affiliation":[{"name":"Haematology, Oncology Unit Bnai\u2010Zion Medical Centre Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Liphshitz","sequence":"additional","affiliation":[{"name":"National Cancer Registry Ministry of Health Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Aviv","sequence":"additional","affiliation":[{"name":"Haematology, Oncology Unit Emek Medical Centre Afula Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Landgren","sequence":"additional","affiliation":[{"name":"Multiple Myeloma Section National Cancer Institute National Institutes of Health Bethesda MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha","family":"Barchana","sequence":"additional","affiliation":[{"name":"School of Public Health Haifa University Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Polliack","sequence":"additional","affiliation":[{"name":"Department of Haematology Hadassah University Hospital and Hebrew University Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-9546-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22765"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010401)91:7<1358::AID-CNCR1139>3.0.CO;2-C"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(02)03065-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605989"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01600.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152586"},{"key":"e_1_2_7_9_1","volume-title":"Assessment of the Completeness of the Israel Cancer Registry Database \u2014 Methods and Findings [in Hebrew]","author":"Fishler Y.","year":"2003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20167"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0895"},{"key":"e_1_2_7_12_1","unstructured":"Israel Central Bureau of Statistics(2007)Death causes in Israel \u2013 2007. 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