{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:54:11Z","timestamp":1787014451819,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T00:00:00Z","timestamp":1332720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We conducted a\n                    <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    hase 1\/2 study of bortezomib administered in combination with high\u2010dose melphalan followed by tandem autologous transplants in patients with primary resistant multiple myeloma. Thirty patients received two cycles of salvage bortezomib followed by stem cell mobilization with granulocyte colony\u2010stimulating factor and harvest. Melphalan 100\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    per day on two consecutive days was administered, immediately followed by one dose of bortezomib (dose escalation) and stem cell infusion. The median beta 2\u2010microglobulin was 4\u00b735\u00a0mg\/l (range: 1\u00b78\u201311\u00b74); albumin was 37\u00a0g\/l (range: 3\u00b71\u20134\u00b79); high\u2010risk karyotypes were noted in 45% of patients. The maximum planned dose of bortezomib at 1\u00b73\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    was well tolerated and a formal maximum tolerated dose was not determined. The peak of best overall response (\u2265partial response) and complete response rates after tandem transplants were 84% and 36%, respectively. With a median follow\u2010up of 48\u00a0months, the median progression\u2010free survival was 15 [95% confidence interval (\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ): 11\u201321] months and the median overall survival was 35 (95% CI: 22\u201343) months. Correlative studies demonstrated decreased expression of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0\u00b70072) and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">FANCF<\/jats:styled-content>\n                    <\/jats:italic>\n                    (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0\u00b70458)\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    following bortezomib treatment. Bortezomib combined with high\u2010dose melphalan is a well\u2010tolerated conditioning with some activity in patients with resistant myeloma.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09099.x","type":"journal-article","created":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T20:39:51Z","timestamp":1332794391000},"page":"553-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Bortezomib salvage followed by a\n                    <scp>P<\/scp>\n                    hase\n                    <scp>I<\/scp>\n                    \/\n                    <scp>II<\/scp>\n                    study of bortezomib plus high\u2010dose melphalan and tandem autologous transplantation for patients with primary resistant myeloma"],"prefix":"10.1111","volume":"157","author":[{"given":"Taiga","family":"Nishihori","sequence":"first","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J.","family":"Alekshun","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Shain","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"},{"name":"Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Experimental Therapeutic Program H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Baz","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Pidala","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Kharfan\u2010Dabaja","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Ochoa\u2010Bayona","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo F.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle N.","family":"Yarde","sequence":"additional","affiliation":[{"name":"Experimental Therapeutic Program H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"},{"name":"Cancer Biology Program H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Experimental Therapeutic Program H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fulp","sequence":"additional","affiliation":[{"name":"Department of Biostatistics H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongphil","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"},{"name":"Department of Biostatistics H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dung\u2010Tsa","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences University of South Florida Tampa FL USA"},{"name":"Department of Biostatistics H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Raychaudhuri","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. 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