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Vascular occlusion of small and large vessels can lead to chronic damage of multiple organs including brain, lung, bone, kidney, liver, spleen, and retina. However, the extent to which <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> impacts myocardial function is not very clear. Cardiovascular manifestations include both right and left ventricular systolic and diastolic dysfunction, elevated cardiac output, cardiomegaly and myocardial ischaemia. Progressive heart damage from iron overload occurs in patients requiring routine transfusion therapy. Pulmonary hypertension resulting from intravascular haemolysis has also been recognized as a major complication that independently correlates with survival. This review summarizes all available data for the heart complications in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> to update the physicians for their appearance, diagnostic procedures and possible management.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09143.x","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T07:33:21Z","timestamp":1335339201000},"page":"664-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Sickle\u2010cell disease and the heart: review of the current literature"],"prefix":"10.1111","volume":"157","author":[{"given":"Ersi","family":"Voskaridou","sequence":"first","affiliation":[{"name":"Thalassaemia Centre Laikon General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Christoulas","sequence":"additional","affiliation":[{"name":"Department of Haematology 251 General 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