{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:43:19Z","timestamp":1792356199730,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The curative potential of allogeneic haematopoietic stem cell transplant (allo <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) in chronic lymphocytic leukaemia <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> is established, with a demonstrated role for graft\u2010versus\u2010leukaemia and less certainty for other factors in determining outcome. The first two decades of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients proceeding to allo <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> at the Leukaemia\/Bone Marrow Transplant Program of British Columbia (<jats:italic>n<\/jats:italic>\u00a0=\u00a049 consecutive, 1991\u20132009) were studied to clarify factors predicting outcome. The donor was related in 29 (59%) and unrelated in 20 (41%). Conditioning was reduced\u2010intensity\u00a0in 27 (55%) and myeloablative in 22 (45%). Thirty\u2010one of 49 patients survive with median follow\u2010up of 5\u00a0years (0\u00b72\u201315). Cumulative incidence of non\u2010relapse mortality; complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>); clearance of fluorescence <jats:italic>in situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) abnormality and progression at 10\u00a0years was 36%; 69%; 55% and 22%. Overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was 63% at 2\u00a0years; 55% at\u00a05\u00a0years and beyond. Factors predicting <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (<jats:italic>P<\/jats:italic> value by log rank &lt;0\u00b705) were: comorbidity index &lt;3, <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> rank\u00a0(Dohner) and 17p deletion, alemtuzumab pre\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, achievement of <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, donor chimerism &gt;90%, clearance of <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> abnormality post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> and absence of high\u2010grade (3\u20134) graft\u2010versus\u2010host disease. Results from this province\u2010wide, two\u2010decade cohort demonstrated that a substantial proportion of patients with high\u2010risk <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> become long term disease\u2010free survivors.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09170.x","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T06:36:04Z","timestamp":1338273364000},"page":"174-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Allogeneic haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: outcome in a 20\u2010year cohort"],"prefix":"10.1111","volume":"158","author":[{"given":"Cynthia L.","family":"Toze","sequence":"first","affiliation":[{"name":"Division of Hematology Leukemia\/BMT Program of British Columbia Vancouver General Hospital BC Cancer Agency University of British Columbia  Vancouver 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