{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:31:20Z","timestamp":1791228680987,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>) is a heterogenic non\u2010Hodgkin lymphoma entity, with a median survival of about 5\u00a0years. In 2008 we reported the early \u2013 based on the median observation time of 4\u00a0years \u2013 results of the Nordic Lymphoma Group <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>2 study of frontline intensive induction immunochemotherapy and autologous stem cell transplantation (<jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>), with more than 60% event\u2010free survival at 5\u00a0years, and no subsequent relapses reported. Here we present an update after a median observation time of 6\u00b75\u00a0years. The overall results are still excellent, with median overall survival and response duration longer than 10\u00a0years, and a median event\u2010free survival of 7\u00b74\u00a0years. However, six patients have now progressed later than 5\u00a0years after end of treatment. The international <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> Prognostic Index (<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>) and Ki\u201067\u2010expression were the only independent prognostic factors. Subdivided by the <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>\u2010Biological Index (<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>\u00a0+\u00a0Ki\u201067, <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>\u2010B), more than 70% of patients with low\u2010intermediate <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>\u2010B were alive at 10\u00a0years, but only 23% of the patients with high <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>\u2010B. These results, although highly encouraging regarding the majority of the patients, underline the need of a risk\u2010adapted treatment strategy for <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>. The study was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.isrctn.org\">www.isrctn.org<\/jats:ext-link> as <jats:styled-content style=\"fixed-case\">ISRCTN<\/jats:styled-content> 87866680.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09174.x","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T02:35:36Z","timestamp":1338258936000},"page":"355-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":240,"title":["Nordic <scp>MCL<\/scp>2 trial update: six\u2010year follow\u2010up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by <scp>BEAM<\/scp> or <scp>BEAC<\/scp>\u00a0+\u00a0autologous stem\u2010cell support: still very long survival but late relapses do occur"],"prefix":"10.1111","volume":"158","author":[{"given":"Christian H.","family":"Geisler","sequence":"first","affiliation":[{"name":"Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Kolstad","sequence":"additional","affiliation":[{"name":"The Norwegian Radium Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Laurell","sequence":"additional","affiliation":[{"name":"Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"R\u00e4ty","sequence":"additional","affiliation":[{"name":"Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kimby","sequence":"additional","affiliation":[{"name":"Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Bentzen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Kuittinen","sequence":"additional","affiliation":[{"name":"Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grete F.","family":"Lauritzsen","sequence":"additional","affiliation":[{"name":"The Norwegian Radium Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Nilsson\u2010Ehle","sequence":"additional","affiliation":[{"name":"Sahlgrenska Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Ralfki\u00e6r","sequence":"additional","affiliation":[{"name":"Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Ehinger","sequence":"additional","affiliation":[{"name":"Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Delabie","sequence":"additional","affiliation":[{"name":"The Norwegian Radium Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja\u2010Liisa","family":"Karjalainen\u2010Lindsberg","sequence":"additional","affiliation":[{"name":"Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brown","sequence":"additional","affiliation":[{"name":"Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkki","family":"Elonen","sequence":"additional","affiliation":[{"name":"Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00093.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.3116"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.7055"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"issue":"4","key":"e_1_2_6_7_1","first-page":"162","article-title":"High\u2010dose Aracytine in induction might counteract the adverse prognostic value of gene copy number alteration in autografted MCL patients. An EUMCL Network study","volume":"22","author":"Delfau\u2010Larue M.","year":"2011","journal-title":"Annals of Oncology"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25756"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3883"},{"key":"e_1_2_6_11_1","article-title":"A multi center trial of hypercvad+rituxan in patients with newly diagnosed mantle cell lymphoma","volume":"110","author":"Epner E.M.","year":"2007","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24141"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-147025"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-236570"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2476"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348367"},{"key":"e_1_2_6_17_1","article-title":"Alternating courses of 3 x CHOP and 3 x DHAP plus rituximab followed by high\u2010dose AraC containing myeloablative regimen and autologous stem cell transplantation (ASCT) is superior to six courses of CHOP plus rituximab followed by myeloablative radiochemotherapy and ASCT in mantle cell lymphoma: results of the MCL younger trial of the European Mantle Cell Lymphoma Network (MCL net)","volume":"116","author":"Hermine O.","year":"2010","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.8435"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095331"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.5.1288"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4079"},{"key":"e_1_2_6_22_1","first-page":"511","article-title":"Hyper\u2010CVAD and high\u2010dose methotrexate\/cytarabine followed by stem\u2010cell transplantation: an active regimen for aggressive mantle\u2010cell lymphoma","volume":"27","author":"Khouri I.F.","year":"1998","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-009-0036-x"},{"key":"e_1_2_6_24_1","article-title":"R\u2010CHOP Versus R\u2010FC Followed by Maintenance with Rituximab Versus Interferon\u2010Alpha: Outcome of the First Randomized Trial for Elderly Patients with Mantle Cell Lymphoma","volume":"118","author":"Kluin\u2010Nelemans J.C.","year":"2011","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_6_25_1","article-title":"High Response Rate After 4 Courses of R\u2010DHAP In Untreated Mantle Cell Lymphoma (MCL) Patients In the Ongoing Phase III Randomized GOELAMS and GELA LyMa Trial","volume":"116","author":"Le Gouill S.","year":"2010","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402406"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.133"},{"key":"e_1_2_6_28_1","first-page":"965","article-title":"R\u2010CHOP\/R\u2010DHAP Compared to R\u2010CHOP Induction Followed by High Dose Therapy with Autologous Stem Cell Transplantation Induces Higher Rates of Molecular Remission In MCL: Results of the MCL Younger Intergroup Trial of the European MCL Network","volume":"116","author":"Pott C.","year":"2010","journal-title":"Blood, (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01677.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.1825"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08228.x"},{"key":"e_1_2_6_32_1","first-page":"168","volume-title":"World Health Organization Classification of Tumours. Pathology & Genetics. Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S.H.","year":"2001"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07498.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1182\/blood.V87.11.4483.bloodjournal87114483","article-title":"Mantle cell lymphoma \u2013 an entity comes of age","volume":"87","author":"Weisenburger D.D.","year":"1996","journal-title":"Blood"}],"updated-by":[{"DOI":"10.1111\/bjh.12006","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000}}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2012.09174.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2012.09174.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:07:08Z","timestamp":1700525228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2012.09174.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,29]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1365-2141.2012.09174.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09174.x","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/bjh.12006","asserted-by":"object"}]},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,29]]},"assertion":[{"value":"2012-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}