{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:25:14Z","timestamp":1791181514376,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"Summary<\/jats:title>The translocation t(14;18) and its t(2;18) and t(18,22) variants, which involve the BCL<\/jats:styled-content>2<\/jats:italic> genetic hallmark for follicular lymphoma (FL<\/jats:styled-content>), have been reported in several cases of chronic B<\/jats:styled-content>\u2010cell lymphoproliferative disease (CLPD<\/jats:styled-content>) and frequently in chronic lymphocytic leukaemia (CLL<\/jats:styled-content>). We describe here the clinical, morphological, immunological, cytogenetic and molecular findings from 37 cases of t(14;18)\u2010positive CLPD<\/jats:styled-content>, identified from our series of non\u2010FL<\/jats:styled-content> B\u2010cell neoplasms (n<\/jats:italic>\u00a0=\u00a0993) that were routinely analysed in peripheral blood by conventional cytogenetics analyses. The FL<\/jats:styled-content> diagnosis was excluded by morphology and immunology (the samples were CD<\/jats:styled-content>10 negative in all cases). The BCL<\/jats:styled-content>2<\/jats:italic> translocations were observed in 22 CLL<\/jats:styled-content> cases, including 7 monoclonal B<\/jats:styled-content>\u2010cell lymphocytosis (MBL<\/jats:styled-content>) cases re\u2010classified according to the new International Workshop on CLL<\/jats:styled-content> criteria, six small lymphocytic lymphoma (SLL<\/jats:styled-content>) cases, 1 splenic marginal zone lymphoma (SMZL<\/jats:styled-content>) case and eight cases of unclassifiable CLPD<\/jats:styled-content> with overlapping CLL<\/jats:styled-content>\/MZL<\/jats:styled-content> features. In the CLL<\/jats:styled-content> cases, the IGH<\/jats:styled-content>\/BCL<\/jats:styled-content>2<\/jats:italic> fusion was remarkably associated with trisomy 12 (13\/22) and mutated IGHV<\/jats:styled-content><\/jats:italic> status (20\/21) and did not affect the outcome. Moreover, most of these CLL<\/jats:styled-content>s harboured a low mutation load of BCL<\/jats:styled-content>6<\/jats:italic> gene and unmutated FAS<\/jats:styled-content><\/jats:italic> (CD<\/jats:styled-content>95<\/jats:italic>) loci, which points to a post\u2013germinal\u2010centre cellular origin.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09178.x","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T07:09:14Z","timestamp":1339484954000},"page":"489-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["In non\u2010follicular lymphoproliferative disorders, IGH<\/scp><\/i>\/BCL<\/scp>2<\/i>\u2010fusion is not restricted to chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"158","author":[{"given":"Lucile","family":"Baseggio","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Biologique"},{"name":"UMR5239 Pathologies des cellules lympho\u00efdes 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